Table 5-3: Concomitant reactions to fragrance markers: Fragrance Mix I and II (FM I, FM II), Myroxylon pereire (MP) and to colophonium (coloph.) in the baseline series in patients with positive or negative patch test reactions to oxidised fragrance substances.

  Total number of pos. and/or neg. reactions   Pos. to FM I     Pos. to MP  Pos. to coloph. Ref.
n %  n  % n %  
Notes: * Bicentric or multicentre studies.
n.g. Not given.
(ox.) Oxidised.  
Reactions to ox. D- limonene and/or limonene hydroperoxide fraction Pos.: 49 20 41   12 24 12 24  (130)*
Neg.: 2751 223  8.1 142 5.2 131 4.8
Reactions to ox. D- limonene and/or limonene hydroperoxide fraction a Pos.: 60 22 37 11 18 13 22  (132)*
Neg.: 729 141 19 71  9.7 58 8
Reactions to ox. D- limonene and/or ox. L- limonene a Pos. to ox. D-limonene: 41  14  34  11  27  11  27  (134)*
Neg. to ox. D-limonene: 1771  113  6.4  91  5.1  62  3.5
Pos. to ox. L- limonene: 36  11  31  12  33  9  25
Neg. to ox. L-limonene: 1776  116  6.5  80  4.5  64  3.6
Reactions to any of ox. linalool, myrcene, caryophyllene Pos. to any of the tested ox. subst.: 31  12  39  6  31  12  39  (133)*
Neg. to any of the tested ox. subst: 1480  93  6  63  4  46  3
      Pos. to FM I Pos. to FM II  Pos. to MP Pos. to coloph.
 n  %  n  %  n  %  n  %  
Reactions to ox. linalool Pos. at test conc. 4%: 30  8  26. 7  5  16. 7  10  33. 3  5  16. 7  (135)*
Pos. at test conc. 6%: 55  12  21. 8  8  14. 5  11  20  8  14. 5
Pos. at test conc. 11%: 72  14  19. 4  9  12. 5  14  19. 4  9  12. 5
Total pos. at any test conc: 75/1004  n.g.    n.g.    n.g    n.g.  
Total neg. at any test conc: 929/1004  56  6.0  29  3.1  45  4.8  24  2.6

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 36-37