Table 5-2: Contact allergic reactions to limonene, linalool, linalyl acetate and caryophyllene in
consecutive dermatitis patient. Please observe that several studies have been performed using the
test substances without reporting the autoxidation status but it has been intended to be low. For
precise information see the original references.
| INCI name |
CAS number |
Test conc. (%) |
n Positive/n tested (%) |
Comments (Ref.) |
Notes: § Bicentric or multicentre studies.
(ox.) Oxidised.
* Stabilised: according to the manufacturer contained additional substances aimed at limiting
oxidation. |
| Limonene |
138-86-3 |
2 |
0/1200 |
(137) |
| Limonene |
3/2396 (0.1%) |
§ (74) |
| DL-Limonene |
11/1241 (0.88%) |
§ (43) |
| Limonene |
0/320 |
(44) |
| DL-Limonene |
3/2396 (0.1%) |
§ (74) |
| Linalool |
78-70-6 |
30 |
0/179 |
(139) |
| |
20 |
3/1825 (0.2%) |
§ (45) |
| |
10 |
2/320 (0.6%) |
(44) |
| |
10 |
4/792 (0.5%) |
(138) |
|
5 and 1 |
0/100 |
(70) |
| Linalool, “stabilised” * |
10 |
7/2401 (0.3%) |
§ (74) |
| 10 |
2/985 (0.2%) |
§ (43) |
| Linalyl acetate |
115-95-7 |
1, 5 |
0/100 |
(70) |
| 10 |
4/1855 (0.2%) |
§ (67) |
| beta-Caryophyllene |
87-44-5 |
5 |
10/1606 (0.6%) |
§ (97) |
Source:
SCCS,  Opinion on Fragrance allergens in cosmetic products, page 36
|