Table 4-5: Results with screening agents for contact allergy to fragrance ingredients reported since 1999 in patients patch tested for suspected allergic contact dermatitis: Fragrance Mix “II” (see Table 4-2). The FM II was only conceived in 2005, so results are still sparse). If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Country (Ref.) Population Year(s) No. tested Crude % positive (95% CI)
EU (35) Six clinical depts. 10/2002-06/2003 1701 2.9
(2.2–3.9)§
IVDK, Germany (68) Consecutive patients 01/2005-12/2008 35633 4.9
(4.7–5.1)§
Groningen, Netherlands (44) Patients (fragrance allergy suspected) 04/2005-06/2007 227 9.3
(5.8–13.8)§
Leuven, Belgium (47) Consecutive patients 2005 only 335 2.1
(0.8–4.3)§
Spain (49) Consecutive patients 10/2005-06/2008 1253 0.6
(0.2–1.1)§
Denmark (69) on behalf of the DCDG, 2010 Consecutive patients 2005-2008 12302 4.5
(4.1–4.9)§

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, page 20