Table 11-6: Overview of dose-response studies and thresholds for eight allergens, after (280).
| Study |
Number of patients |
ED10 (μg/cm2) |
95 % interval |
Note: The ED10 value is the concentration which elicits an allergic reaction in 10% of a group of
sensitised individuals under patch test conditions. |
| MCI/MI |
12 |
1.05 |
0.17–2.27 |
| Formaldehyde |
20 |
20.1 |
4.09–43.9 |
| Nickel 1997 |
24 |
1.58 |
0.32–4.04 |
| Nickel 1998 |
19 |
0.8 |
0.078–2.59 |
| Study |
Number of patients |
ED10 (μg/cm2) |
95 % interval |
| Nickel 1999 |
26 |
7.49 |
2.42–14.5 |
| Nickel 2005 |
13 |
0.74 |
0.066–2.38 |
| Nickel 2007 |
20 |
0.82 |
0.13–2.37 |
| Cobalt 2005 |
11 |
0.44 |
0.033–1.3 |
| Chromium |
17 |
1.04 |
0.0033–5.55 |
| Isoeugenol 2001 |
24 |
1.48 |
0.22–4.74 |
| Isoeugenol 2005 |
13 |
0.23 |
0.0073–1.32 |
| HICC 2003 |
18 |
0.85 |
0.062–3.26 |
| HICC 2007 |
14 |
1.17 |
0.043–5.05 |
| HICC 2009 |
17 |
0.66 |
0.052–2.35 |
| MDBGN 2004 |
19 |
0.025 |
0.00021–0.19 |
| MDBGN 2008 |
18 |
0.50 |
0.052–1.69 |
Table 11-6 presented graphically, after (280).
Source:
SCCS, 
Opinion on Fragrance allergens in cosmetic products, pages 95-96