Figure 11-1: The fitted dose-response curve for patch test

The fitted dose-response curve for patch test (solid line) is seen to be displaced to the right compared to the observed response from repeated open applications of the same allergen (HICC). It means that a smaller dose per application is needed to elicit a response than by one single occluded application as in the patch test.

fitted dose-response curve for patch test

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 89-90