Summary sheet on Commission
Review (Ref XXIV/1285/97)
Ingredient :
1,5-dihydroxynaphthalene
CAS n°: 83-56-7
Function and max in use
concentration: oxidative hair
dye; max 1 %, 0.5 % with H2O2
Assessment of acute
toxicity (dermal, oral, i.v.,
i.p.):
Moderate oral acute
toxicity
Assessment of irritation
& corrosivity:
No irritative effects
neither on mucous membranes nor
on the skin
Assessment of
chronic/subchronic toxicity:
Repeated dose toxicity
- 90 d
Assessment of
reproductive toxicity:
No signs of
embryotoxicity or
teratogenicity as well as of
maternal toxicity within
reasonable dose ranges
Assessment of
genotoxicity/carcinogenicity:
Equivocal results in in
vitro studies, no evidence of
mutagenic activities in in vivo
testing
Assessment of
allergenicity/sensitization:
No evidence of
sensitization
Percutaneous absorption:
In in vivo experiments
with hair dye preparations and
using radiolabelled test
substance the absorption rate
was low, leading to an
appropriate "safety margin"
Classification: 1
Statement on the
toxicological evaluation
The SCCNFP is the
scientific advisory body to the
European Commission in matters
of consumer protection with
respect to cosmetics and
non-food products intended for
consumers.
The Commission's general
policy regarding research on
animals supports the
development of alternative
methods to reduce animal
testing when possible. In this
context, the SCCNFP has a
specific working group on
alternatives to animal testing
which, in co-operation with
other Commission services such
as ECVAM (European Centre for
Validation of Alternative
Methods), evaluates these
methods.
SCCNFP opinions include
evaluations of experiments
using laboratory animals; such
tests are conducted in
accordance with all legal
provisions and preferably under
chemical law regulations. Only
in cases where no alternative
method is available will such
tests be evaluated and the
resulting data accepted, in
order to meet the fundamental
requirements of the protection
of consumer health.