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Directorate-General for Health and Food Safety
The Chairman, Prof. Kemper, welcomed the
participants of the meeting (see annex) and
introduced as guest speaker Dr. David
Basketter who was invited for a presentation
and discussion on 'Fragrance materials, the
phenomenon of quenching'.
Apologies were received from some members of the SCCNFP (see annex)
0. Lecture on 'Quenching - a review in relation to fragrance allergy' Dr. David Basketter
In the framework of the safety evaluation of fragrance materials, Dr. Basketter was invited to illustrate the phenomenon of quenching.
The concept is that skin sensitisation can be blocked by a suitable "antagonist" - which may also be a scent - present at an appropriate concentration. However, examination of quenching pairs has failed to find any evidence of (physico-)chemical interactions which would explain the phenomenon of quenching. Nor could quenching be demonstrated at the level of skin reactions at either induction or elicitation in any guinea pig/murine skin sensitisation models or at the level of elicitation in allergic subjects.
Although there is no convincing scientific evidence that quenching occurs or a clear hypothesis for why it should, certain observations imply that there may be a phenomenon which is worthy of further careful investigation.
The presentation was followed by a discussion, and in particular on sensitisation testing on human volunteers in the light of ethical premises.
1. Declaration of interest
No interests were declared.
2. Adoption of the Agenda (doc. n° SCCNFP/0253/99) (Annex 1)
The agenda was adopted.
3. Approval of the minutes of the 9th plenary meeting of 30 September 1999
doc. n° SCCNFP/0204/99
The minutes were adopted.
4. SCCNFP - Specific Working Parties
4.1 Alternatives
Report of the Co-ordinator
In his report, Prof. Loprieno, presented the following items :
- the updating of the notes of guidance concerning the definition of and the data on consumer exposure to cosmetic ingredients, in particular the exposure to preservatives, UV filters and hair dyes;
- preparatory work on an additional annex to the notes of guidance concerning the physical and chemical specifications of new ingredients including ingredients derived from plants or animal tissues;
- the use of human volunteers for the skin compatibility testing of potentially cutaneous irritant ingredients or mixtures of ingredients. A draft opinion was prepared on the issue;
- the use of human volunteers for the testing of potentially sensitising ingredients or mixture of ingredients. The main point of concern is the ethical aspects;
In his report, the Co-ordinator mentioned as well that it was regrettable that DG Research approved only one research project in the framework of the 'Cell factory' research programme. He regretted that no appropriate response was given to the call for an extensive research programme on development of alternatives to animal testing.
A draft opinion on :
Basic criteria of the protocols for the skin compatibility testing of potentially cutaneous irritant cosmetic ingredients or mixtures of ingredients on human volunteers, doc. n° SCCNFP/0245/99, rev. 2
In the framework of the recently adopted guidelines on the use of human volunteers in the testing of potentially cutaneous irritant cosmetic ingredients or mixture of ingredients, the Working Party prepared a document which specifies the basic criteria for study protocols for skin compatibility testing of such ingredients or mixture of ingredients. The document did intentionally not go into all the details of the study design as there is at present no standard study design. Therefore, the document specifies the more general criteria, and consequently limits, applicable to the various study designs.
The document states that the study protocol should contain, amongst others, information on the purity of the ingredients and on the nature of the vehicle. In this respect, Prof. Loprieno mentioned that the Working Party is considering these issues in view of a possible inclusion in the Notes of Guidance. He said that the item is on the agenda of the next WP meeting, scheduled on 31 January 2000.
As a result of the discussion, the document was adopted by the plenary meeting. It will be included in the Committee's Notes of Guidance for Testing of Cosmetic Ingredients for their Safety Evaluation.
In the margin of the discussion, Prof. Kemper suggested the Commission to send a copy of the document to the Commission's Ethical Committee (SG).
4.2 Hair Dyes
Report of the Co-ordinator
In his report, Prof. Andersen mentioned the following items :
- on 18 -20 October, a Special Task Force meeting took place during which 15 draft opinions were prepared. 13 of these draft opinions were discussed by the Working Party on 7 December. The WP approved 5 draft opinions and addressed them to the next plenary for formal adoption. On the 8 remaining draft opinions, additional data were requested from industry.
2 draft opinions were postponed to the next WP meeting.
- the SCCNFP was requested to evaluate the risk of amino acids derived from human hair hydrolysates with regard to the transmission of Creutzfeldt Jakob Disease, transmissible human spongiform encephalopathies and viral diseases. The use of this material as cosmetic ingredients is at present prohibited by entry 416 of Annex II of the cosmetics directive. The request seeks a potential modification to entry 416 of Annex II. A rapporteur was assigned who will report in a future meeting.
- elucidations on some recently adopted hair dye opinions were asked by the Austrian Delegation. The questions asked will be dealt with in the next WP meeting.
4.3 Inventory
Report of the Co-ordinator
In his report, the co-ordinator, Prof. Parra, said that no meetings were organised since the previous plenary meeting of 30.9.99, but that work will resume upon receipt of the final draft of the 1st update of the inventory.
As it was said that the final draft would be available by mid-December, a meeting was planned on 20 December 1999 to consider the document and to decide on how to proceed in view of its adoption by the plenary.
4.4 Preservatives, Colorants & Fragrances
Report of the Co-ordinator
In his report, the Co-ordinator, Dr. White informed the plenary about a letter received from a company requesting the Commission to freeze the procedure to put the SCCNFP opinion concerning Ketoconazole into legislation, to discuss the SCCNFP opinion with their experts and to revise the opinion by limiting the use of the chemical up to 1.0% in rinse-off and to 0.5% in leave on products.
Dr. White asked the committee members to comment on this. As a result, the SCCNFP restated the opinion adopted and requested the Commission to respond to the firm in that respect.
Draft opinions on Musk Ketone and Musk Xylene
Dr. White introduced the issue saying that the Plenary meeting of 30 September 1999 decided to refer the draft opinions on Musk Ketone and Musk Xylene back to the Working Party as there was still concern about carcinogenicity, their accumulation in mother's milk and an acceptable concentration in the finished product. All members were invited to go through the document and to respond with any questions regarding information they would like to see or any points for clarification they would like to raise.
Two more Working Party meetings were organised during which the comments received from the members were discussed and the opinions redrafted. The final drafts were tabled for formal adoption.
Musk Xylene, doc. n° SCCNFP/0162/99, rev. 5
As the draft opinion has already been discussed in detail during previous meetings, the discussion today focussed mainly on the wording of the opinion. The committee stated that the aim of the opinion was a reduction in consumer exposure to Musk Xylene of about 50%.
The basis to achieve this was the estimated exposure to Musk Xylene of about 207 μg/kg bw/day, which equated to about 20.7 μg/kg bw/day absorbed. As it was not possible to identify a threshold dose from the mice tumour data, the committee said that the absorbed dose of Musk Xylene from exposure to cosmetic products should be reduced to about 10 μg/kg bw/day. This statement was based on the quantitative risk assessment assuming that a calculated lifetime cancer risk of about 1 x 10-4 should be tolerable for a non-genotoxic carcinogen.
It was recognised that the proposed reduction could be achieved in a number of ways and the following were given as examples :
* a maximum of 0.1 % Musk Xylene in any cosmetic product would give a calculated absorbed dose of about 10.3 μg/kg bw/day;
* a concentration of 1.0 % in perfume, of 0.4 % in eau de toilette and a concentration of 0.03 % in all other products would give a calculated absorbed dose of about 10.8 μg/kg bw/day.
The Committee stressed that the above was formulated on review of only the cosmetic use of Musk Xylene and that for a complete safety assessment of Musk Xylene, also other sources of consumer exposure from non-food products e. g., laundry products should be considered.
The opinion was adopted by the plenary.
Musk Ketone, doc. n° SCCNFP/0162/99, rev. 5
To a certain extend, the same was said concerning Musk Ketone, as there are a number of similarities with Musk Xylene. The key issue was that there were no carcinogenicity studies available on Musk Ketone. However, Musk Ketone is non-genotoxic and behaves like phenobarbital (enzyme induction). So, one might assume that there is no risk of carcinogenicity.
The committee stated that the aim of the opinion was also a reduction in consumer exposure to Musk Ketone of 50%. The estimated exposure to Musk Ketone is about 200 μg/kg bw/day, which equates to about 28 μg/kg bw/day absorbed. The committee said that the absorbed dose of Musk Ketone from exposure to cosmetic products should be reduced by about 50 % to about 14 μg/kg bw/day and that the proposed reduction could be achieved following the same approaches as suggested for Musk Xylene.
Again, the Committee stressed that the above was formulated on review of only the cosmetic use of Musk Ketone and that for a complete safety assessment of Musk Ketone, other sources of consumer exposure from non-food products e. g., laundry products should be considered.
The opinion was adopted by the plenary.
Draft Pre-opinion concerning fragrance allergy in consumers, doc. n° SCCNFP/0017/98
During the 9th plenary meeting of 30.9.99, the Committee approved the draft pre-opinion concerning fragrance allergens and requested the Commission to put it on the internet to invite interested parties for comments before 2 November 1999.
The comments (39) received were divided into two groups, namely personal from individuals suffering from allergies caused by fragrances and comments from industry/scientists on the issue as a whole. The committee considered every comment and discussed their main observations. The observations were catalogued as follows :
- size of the problem/epidemiology
- substances about which the consumer should be informed
- establishment of threshold concentrations
- cross sensitisation (cross reaction)
- fragrance free approach.
As a result, the committee adopted the opinion on fragrance allergy, doc. n° SCCNFP/0017/98 without modifying its content but subject to the insertion of an executive summary as well as the paper 'Comments on the draft pre-opinion concerning fragrance allergy in consumers', doc. n° SCCNFP/0261/99 which lists the critical comments and questions received together with the response of the committee.
A tabulated list of the comments received and the reply from the committee on these comments (doc. n° SCCNFP/0261/99) are available on request.
4.5 UV Filters
Report of the Co-ordinator
Although no further Working Party meetings have taken place since the previous plenary meeting of 30 September 99, the co-ordinator, Dr Lina reported on the state of the pending issues :
* S75 : Coated Titanium dioxide : a letter was sent in July 99 requiring industry to respond specifically to the questions asked. Industry replied they will respond to each of the questions asked before the end of the year. Work will resume upon receipt of the data.
5. Report on the European Legal Framework on Detergents SCCNFP/0250/99
J. Lopez Villar
Recently, the Commission's attention was drawn to the skin problems caused by detergents or other household products. However, the existing legislation in this domain focuses mainly on environmental/general health issues rather than on possible skin diseases.
Mr. Lopez Villar presented an overview of the EU legal framework on detergents. Two main pieces of legislation exist, namely the specific legislation on detergents and the legislation on dangerous substances and preparations.
Although, at present, the consultation of the SCCNFP on the issue is not mandatory, it was decided to establish a Special Working Party and to look for additional external experts in this field to enable the SCCNFP to answer the respective mandates.
6. Report of the Chairman
In the light of the 6th amendment to Directive 76/768/EEC, Prof. Kemper invited the members to reflect on the possibility to propose a separate chapter in Annex III to the cosmetics directive listing the pharmacological active substances used in cosmetics with a distinct action on the skin or its annexes.
7. Any Other Business
* The following dates were proposed for future plenary meetings : 17 February 2000,
3 May 2000 and 28 June 2000.
Attendance List
Present : Mr K.E. Andersen, Mr R. Anton, Mr J-F. Doré, Mr P. Elsner, Mr V. Kapoulas, Mr F. Kemper, Mr B. Lina, Mr N. Loprieno, Mr J. Parra, Mrs V. Rogiers, Mr T. Sanner, Mr J. Vives Rego, Mr I. White
Mrs J.D. Johansen external expert, Mr D. O'Mahony external expert, Mrs R. Schumann external expert
Commission : Mrs L. Benali DG Sanco, Mrs S. Clarke DG Sanco, Mrs M. de Solà DG Sanco, Mrs F. Drion DG Sanco, Mr J. Lopez Villar DG Sanco, Mr L. Norgaard DG Entr, Mr A. Van Elst DG Sanco
Apologies : Mr P. Blain Mr Ph. Masson external expert
Annex 1
Scientific Committee on Cosmetic and Non-Food Products
Agenda for the 10th plenary meeting (Brussels, 8 December 1999)
0. Lecture on 'Fragrance materials, the phenomenon of quenching'
Dr. David Basketter
1. Declaration of interest
2. Adoption of the agenda SCCNFP/0253/99
3. Approval of the minutes of the 9th plenary meeting of 30.9.99 SCCNFP/0223/99
4. SCCNFP - Specific Working Parties
4.1 Alternatives
Report of the Co-ordinator
Draft opinion on minimal criteria of the protocols for the skin compatibility testing of potentially cutaneous irritant cosmetic ingredients or mixtures of ingredients on human volunteers SCCNFP/0245/99 rev.1
4.2 UV Filters
Report of the Co-ordinator
* Further procedure S75
4.3 Hair Dyes
Report of the Co-ordinator
4.4 Inventory
Report of the Co-ordinator
4.5 Preservatives, Colorants and Fragrances
Report of the Co-ordinator
* Draft opinion on Musk Xylene SCCNFP/0162/99
* Draft opinion on Musk Ketone SCCNFP/0163/99
* Fragrance Allergens SCCNFP/0017/98
5. Report on the European Legal Framework on Detergents SCCNFP/0250/99
J. Lopez Villar
6. Report of the Chairman
7. Any other business
Apologies were received from some members of the SCCNFP (see annex)
0. Lecture on 'Quenching - a review in relation to fragrance allergy' Dr. David Basketter
In the framework of the safety evaluation of fragrance materials, Dr. Basketter was invited to illustrate the phenomenon of quenching.
The concept is that skin sensitisation can be blocked by a suitable "antagonist" - which may also be a scent - present at an appropriate concentration. However, examination of quenching pairs has failed to find any evidence of (physico-)chemical interactions which would explain the phenomenon of quenching. Nor could quenching be demonstrated at the level of skin reactions at either induction or elicitation in any guinea pig/murine skin sensitisation models or at the level of elicitation in allergic subjects.
Although there is no convincing scientific evidence that quenching occurs or a clear hypothesis for why it should, certain observations imply that there may be a phenomenon which is worthy of further careful investigation.
The presentation was followed by a discussion, and in particular on sensitisation testing on human volunteers in the light of ethical premises.
1. Declaration of interest
No interests were declared.
2. Adoption of the Agenda (doc. n° SCCNFP/0253/99) (Annex 1)
The agenda was adopted.
3. Approval of the minutes of the 9th plenary meeting of 30 September 1999
doc. n° SCCNFP/0204/99
The minutes were adopted.
4. SCCNFP - Specific Working Parties
4.1 Alternatives
Report of the Co-ordinator
In his report, Prof. Loprieno, presented the following items :
- the updating of the notes of guidance concerning the definition of and the data on consumer exposure to cosmetic ingredients, in particular the exposure to preservatives, UV filters and hair dyes;
- preparatory work on an additional annex to the notes of guidance concerning the physical and chemical specifications of new ingredients including ingredients derived from plants or animal tissues;
- the use of human volunteers for the skin compatibility testing of potentially cutaneous irritant ingredients or mixtures of ingredients. A draft opinion was prepared on the issue;
- the use of human volunteers for the testing of potentially sensitising ingredients or mixture of ingredients. The main point of concern is the ethical aspects;
In his report, the Co-ordinator mentioned as well that it was regrettable that DG Research approved only one research project in the framework of the 'Cell factory' research programme. He regretted that no appropriate response was given to the call for an extensive research programme on development of alternatives to animal testing.
A draft opinion on :
Basic criteria of the protocols for the skin compatibility testing of potentially cutaneous irritant cosmetic ingredients or mixtures of ingredients on human volunteers, doc. n° SCCNFP/0245/99, rev. 2
In the framework of the recently adopted guidelines on the use of human volunteers in the testing of potentially cutaneous irritant cosmetic ingredients or mixture of ingredients, the Working Party prepared a document which specifies the basic criteria for study protocols for skin compatibility testing of such ingredients or mixture of ingredients. The document did intentionally not go into all the details of the study design as there is at present no standard study design. Therefore, the document specifies the more general criteria, and consequently limits, applicable to the various study designs.
The document states that the study protocol should contain, amongst others, information on the purity of the ingredients and on the nature of the vehicle. In this respect, Prof. Loprieno mentioned that the Working Party is considering these issues in view of a possible inclusion in the Notes of Guidance. He said that the item is on the agenda of the next WP meeting, scheduled on 31 January 2000.
As a result of the discussion, the document was adopted by the plenary meeting. It will be included in the Committee's Notes of Guidance for Testing of Cosmetic Ingredients for their Safety Evaluation.
In the margin of the discussion, Prof. Kemper suggested the Commission to send a copy of the document to the Commission's Ethical Committee (SG).
4.2 Hair Dyes
Report of the Co-ordinator
In his report, Prof. Andersen mentioned the following items :
- on 18 -20 October, a Special Task Force meeting took place during which 15 draft opinions were prepared. 13 of these draft opinions were discussed by the Working Party on 7 December. The WP approved 5 draft opinions and addressed them to the next plenary for formal adoption. On the 8 remaining draft opinions, additional data were requested from industry.
2 draft opinions were postponed to the next WP meeting.
- the SCCNFP was requested to evaluate the risk of amino acids derived from human hair hydrolysates with regard to the transmission of Creutzfeldt Jakob Disease, transmissible human spongiform encephalopathies and viral diseases. The use of this material as cosmetic ingredients is at present prohibited by entry 416 of Annex II of the cosmetics directive. The request seeks a potential modification to entry 416 of Annex II. A rapporteur was assigned who will report in a future meeting.
- elucidations on some recently adopted hair dye opinions were asked by the Austrian Delegation. The questions asked will be dealt with in the next WP meeting.
4.3 Inventory
Report of the Co-ordinator
In his report, the co-ordinator, Prof. Parra, said that no meetings were organised since the previous plenary meeting of 30.9.99, but that work will resume upon receipt of the final draft of the 1st update of the inventory.
As it was said that the final draft would be available by mid-December, a meeting was planned on 20 December 1999 to consider the document and to decide on how to proceed in view of its adoption by the plenary.
4.4 Preservatives, Colorants & Fragrances
Report of the Co-ordinator
In his report, the Co-ordinator, Dr. White informed the plenary about a letter received from a company requesting the Commission to freeze the procedure to put the SCCNFP opinion concerning Ketoconazole into legislation, to discuss the SCCNFP opinion with their experts and to revise the opinion by limiting the use of the chemical up to 1.0% in rinse-off and to 0.5% in leave on products.
Dr. White asked the committee members to comment on this. As a result, the SCCNFP restated the opinion adopted and requested the Commission to respond to the firm in that respect.
Draft opinions on Musk Ketone and Musk Xylene
Dr. White introduced the issue saying that the Plenary meeting of 30 September 1999 decided to refer the draft opinions on Musk Ketone and Musk Xylene back to the Working Party as there was still concern about carcinogenicity, their accumulation in mother's milk and an acceptable concentration in the finished product. All members were invited to go through the document and to respond with any questions regarding information they would like to see or any points for clarification they would like to raise.
Two more Working Party meetings were organised during which the comments received from the members were discussed and the opinions redrafted. The final drafts were tabled for formal adoption.
Musk Xylene, doc. n° SCCNFP/0162/99, rev. 5
As the draft opinion has already been discussed in detail during previous meetings, the discussion today focussed mainly on the wording of the opinion. The committee stated that the aim of the opinion was a reduction in consumer exposure to Musk Xylene of about 50%.
The basis to achieve this was the estimated exposure to Musk Xylene of about 207 μg/kg bw/day, which equated to about 20.7 μg/kg bw/day absorbed. As it was not possible to identify a threshold dose from the mice tumour data, the committee said that the absorbed dose of Musk Xylene from exposure to cosmetic products should be reduced to about 10 μg/kg bw/day. This statement was based on the quantitative risk assessment assuming that a calculated lifetime cancer risk of about 1 x 10-4 should be tolerable for a non-genotoxic carcinogen.
It was recognised that the proposed reduction could be achieved in a number of ways and the following were given as examples :
* a maximum of 0.1 % Musk Xylene in any cosmetic product would give a calculated absorbed dose of about 10.3 μg/kg bw/day;
* a concentration of 1.0 % in perfume, of 0.4 % in eau de toilette and a concentration of 0.03 % in all other products would give a calculated absorbed dose of about 10.8 μg/kg bw/day.
The Committee stressed that the above was formulated on review of only the cosmetic use of Musk Xylene and that for a complete safety assessment of Musk Xylene, also other sources of consumer exposure from non-food products e. g., laundry products should be considered.
The opinion was adopted by the plenary.
Musk Ketone, doc. n° SCCNFP/0162/99, rev. 5
To a certain extend, the same was said concerning Musk Ketone, as there are a number of similarities with Musk Xylene. The key issue was that there were no carcinogenicity studies available on Musk Ketone. However, Musk Ketone is non-genotoxic and behaves like phenobarbital (enzyme induction). So, one might assume that there is no risk of carcinogenicity.
The committee stated that the aim of the opinion was also a reduction in consumer exposure to Musk Ketone of 50%. The estimated exposure to Musk Ketone is about 200 μg/kg bw/day, which equates to about 28 μg/kg bw/day absorbed. The committee said that the absorbed dose of Musk Ketone from exposure to cosmetic products should be reduced by about 50 % to about 14 μg/kg bw/day and that the proposed reduction could be achieved following the same approaches as suggested for Musk Xylene.
Again, the Committee stressed that the above was formulated on review of only the cosmetic use of Musk Ketone and that for a complete safety assessment of Musk Ketone, other sources of consumer exposure from non-food products e. g., laundry products should be considered.
The opinion was adopted by the plenary.
Draft Pre-opinion concerning fragrance allergy in consumers, doc. n° SCCNFP/0017/98
During the 9th plenary meeting of 30.9.99, the Committee approved the draft pre-opinion concerning fragrance allergens and requested the Commission to put it on the internet to invite interested parties for comments before 2 November 1999.
The comments (39) received were divided into two groups, namely personal from individuals suffering from allergies caused by fragrances and comments from industry/scientists on the issue as a whole. The committee considered every comment and discussed their main observations. The observations were catalogued as follows :
- size of the problem/epidemiology
- substances about which the consumer should be informed
- establishment of threshold concentrations
- cross sensitisation (cross reaction)
- fragrance free approach.
As a result, the committee adopted the opinion on fragrance allergy, doc. n° SCCNFP/0017/98 without modifying its content but subject to the insertion of an executive summary as well as the paper 'Comments on the draft pre-opinion concerning fragrance allergy in consumers', doc. n° SCCNFP/0261/99 which lists the critical comments and questions received together with the response of the committee.
A tabulated list of the comments received and the reply from the committee on these comments (doc. n° SCCNFP/0261/99) are available on request.
4.5 UV Filters
Report of the Co-ordinator
Although no further Working Party meetings have taken place since the previous plenary meeting of 30 September 99, the co-ordinator, Dr Lina reported on the state of the pending issues :
* S75 : Coated Titanium dioxide : a letter was sent in July 99 requiring industry to respond specifically to the questions asked. Industry replied they will respond to each of the questions asked before the end of the year. Work will resume upon receipt of the data.
5. Report on the European Legal Framework on Detergents SCCNFP/0250/99
J. Lopez Villar
Recently, the Commission's attention was drawn to the skin problems caused by detergents or other household products. However, the existing legislation in this domain focuses mainly on environmental/general health issues rather than on possible skin diseases.
Mr. Lopez Villar presented an overview of the EU legal framework on detergents. Two main pieces of legislation exist, namely the specific legislation on detergents and the legislation on dangerous substances and preparations.
Although, at present, the consultation of the SCCNFP on the issue is not mandatory, it was decided to establish a Special Working Party and to look for additional external experts in this field to enable the SCCNFP to answer the respective mandates.
6. Report of the Chairman
In the light of the 6th amendment to Directive 76/768/EEC, Prof. Kemper invited the members to reflect on the possibility to propose a separate chapter in Annex III to the cosmetics directive listing the pharmacological active substances used in cosmetics with a distinct action on the skin or its annexes.
7. Any Other Business
* The following dates were proposed for future plenary meetings : 17 February 2000,
3 May 2000 and 28 June 2000.
Attendance List
Present : Mr K.E. Andersen, Mr R. Anton, Mr J-F. Doré, Mr P. Elsner, Mr V. Kapoulas, Mr F. Kemper, Mr B. Lina, Mr N. Loprieno, Mr J. Parra, Mrs V. Rogiers, Mr T. Sanner, Mr J. Vives Rego, Mr I. White
Mrs J.D. Johansen external expert, Mr D. O'Mahony external expert, Mrs R. Schumann external expert
Commission : Mrs L. Benali DG Sanco, Mrs S. Clarke DG Sanco, Mrs M. de Solà DG Sanco, Mrs F. Drion DG Sanco, Mr J. Lopez Villar DG Sanco, Mr L. Norgaard DG Entr, Mr A. Van Elst DG Sanco
Apologies : Mr P. Blain Mr Ph. Masson external expert
Annex 1
Scientific Committee on Cosmetic and Non-Food Products
Agenda for the 10th plenary meeting (Brussels, 8 December 1999)
0. Lecture on 'Fragrance materials, the phenomenon of quenching'
Dr. David Basketter
1. Declaration of interest
2. Adoption of the agenda SCCNFP/0253/99
3. Approval of the minutes of the 9th plenary meeting of 30.9.99 SCCNFP/0223/99
4. SCCNFP - Specific Working Parties
4.1 Alternatives
Report of the Co-ordinator
Draft opinion on minimal criteria of the protocols for the skin compatibility testing of potentially cutaneous irritant cosmetic ingredients or mixtures of ingredients on human volunteers SCCNFP/0245/99 rev.1
4.2 UV Filters
Report of the Co-ordinator
* Further procedure S75
4.3 Hair Dyes
Report of the Co-ordinator
4.4 Inventory
Report of the Co-ordinator
4.5 Preservatives, Colorants and Fragrances
Report of the Co-ordinator
* Draft opinion on Musk Xylene SCCNFP/0162/99
* Draft opinion on Musk Ketone SCCNFP/0163/99
* Fragrance Allergens SCCNFP/0017/98
5. Report on the European Legal Framework on Detergents SCCNFP/0250/99
J. Lopez Villar
6. Report of the Chairman
7. Any other business
