| 0.5% Calcium peroxide toothpaste |
25 subjects |
applied 4 times a day for 10 days, then 14 days rest and then applied twice on day 25 |
No adverse events in treatment group* |
| 0.5% Calcium peroxide toothpaste |
232 subjects |
daily brushing for 7 weeks |
Examination at 2, 5 and 7 weeks showed no treatment-related effects* |
| Sodium percarbonate toothpaste (0.75% H2O2) |
74 subjects |
6 months |
Transient angular cheilitis in one subject* |
| toothpaste (0.75% H2O2) |
100 subjects |
3 months |
No product-related findings* |
| 0.75% H2O2 with 5% NaHCO3 toothpaste |
25 patients |
twice daily brushing for 28 days after maxillary flap Gingival surgery (bilateral- double-blind cross over study) |
No unwanted effects reported.
75% of patients preferred test product to control (Dentino et al., 1995) |
| 0.75% H2O2 with 5% NaHCO3 toothpaste |
62 subjects + 21 controls |
twice daily brushing for 6 months |
Oral lesions reported in 3 treated patients and 4 controls (Fischman et al., 1992) |
| 0.75% H2O2 toothpaste |
71 subjects |
3 weeks |
An adverse effect was reported by one subject in the treatment group and one control* |
| 0.75% and 1.5% H2O2 toothpaste |
293 subjects |
3 weeks |
24 reports of oral lesions in the active treatment groups; 46 reports in the control group*
5 reports in each of the treated and control groups*
No soft tissue changes associated with either test or control product (Fischman et al. [Abstract], 1992b) |
| 0.75% H2O2 toothpaste |
279 subjects |
|
|
| 1.5% H2O2 with 10% NaHCO3 toothpaste |
60 subjects + 20 controls |
twice daily brushing for 6 months |
|
