Table 3.5. Effect on gastro-duodenal carcinogenesis induced by MNNG (Takahashi et al, 1986)
| Treatment group (n) |
Forestomach
papilloma |
Fundus hyperplasiaa |
Glandular stomach |
Duodenum adeno- carcinoma |
a Adenomatous hyperplasia
b Number of rats with
tumours (%) |
| |
|
|
Pylorus adeno-
carcinoma |
Pre-
neoplastic hyperplasia |
|
| MNNG controls (30) |
0 (0%)
b |
0 (0%) |
1 (3.3%) |
7 (23.3%) |
3 (10%) |
MNNG-
H2O2(21) |
21 (100%) |
8 (38.1%) |
2 (9.5%) |
6 (28.6%) |
0 (0%) |
| H2O2(10) |
5 (50%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
Source:
SCCP
Opinion on Hydrogen peroxide, in its free form or when released, in oral hygiene products (2007), p.31
