Table 3.3. Incidence of gastro-duodenal lesions in C57BL/6J mice after receiving hydrogen peroxide in the drinking water (Ito et al., 1981)
Concentration in drinking water (%) |
Duodenum |
Hyperplasia |
Adenoma |
Carcinoma |
Males |
Females |
Males |
Females |
Males |
Females |
0 |
2 (14%) |
7 (14%) |
0 (2%) |
1 (2%) |
0 (0%) |
0 (0%) |
0.1 |
16 (48%) |
24 (48%) |
2 (4%) |
4 (8%) |
1 (2%) |
0 (0%) |
0.4 |
30 (63%) |
31 (63%) |
2 (4 %) |
0 (0%) |
1 (2%) |
4 (8%) |
Source:
SCCP
Opinion on Hydrogen peroxide, in its free form or when released, in oral hygiene products (2007), p.29