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Table 3.3. Incidence of gastro-duodenal lesions in C57BL/6J mice after receiving hydrogen peroxide in the drinking water (Ito et al., 1981)

Concentration in drinking water (%) Duodenum
Hyperplasia   Adenoma   Carcinoma
Males Females Males Females Males Females
0 2 (14%) 7 (14%) 0 (2%) 1 (2%) 0 (0%) 0 (0%)
0.1 16 (48%) 24 (48%) 2 (4%) 4 (8%) 1 (2%) 0 (0%)
0.4 30 (63%) 31 (63%) 2 (4 %) 0 (0%) 1 (2%) 4 (8%)

Source: SCCP  Opinion on Hydrogen peroxide, in its free form or when released, in oral hygiene products (2007), p.29