Building on the success of previous research framework programmes, this brochure presents a selection of twelve examples showing how research and innovation activities conducted by SMEs make a real difference to EU citizens’ everyday lives, in fields as varied as health, construction, eco-tourism or agriculture. This series of stories illustrates that research & innovation hold business opportunities for SMEs, and that innovation is easier to achieve in well-balanced partnerships, where organizations can complement each other in order to accomplish a successful go-to-market and sustainable competitiveness.