Survival of cancer and diabetes define two morbidities with growing prevalence and marked specificities. Gender profile affects specific areas, like breast cancer, which leaves women in a deteriorated health state and increased vulnerability. We aim at implementing healthy lifestyle, including nutrition and physical activity, to reduce the burden of frailty and of chronic diseases with strong gender profile, mainly musculoskeletal (osteoporosis) and cognitive decline, in women surviving cancer or suffering diabetes. Improvement of mood and quality of life are additional objectives. To reinforce scalability, the commitment in embedded into the CARMEN program, which provides integrated care at primary care level of the public health system. Nurses, who share with social workers first assessment and monitoring, initiate enrolment in the programme. Referral to primary care doctors or the third level specialist (gynaecologist) is done when required. Empowerment is strengthened by the use of an ICT-based program (mobile-based) and by the involvement of patients associations. Adherence in the long term and sustainability are promoted in that way. Collaborative work with other EIPAHA partners materialises in sharing of screening and monitoring tools. Further, the commitment is inserted within the Valencia reference site. Clinical and analytical data are kept in a database while serum and ADN samples are stored in bio-bank. A parallel basic and clinical research program is attached to the initiative.