The aim is the reduction of frailty and chronic diseases with strong gender profile, mainly musculoskeletal (osteoporosis) and cognitive decline, through the implementation of healthy lifestyle. Our population is composed of the women entering the cohort Chronic Ailment Reduction after MENopause (CARMEN, 1400 community dwelling women from the urban area of Valencia). Women initiate a program of integrated care, where primary care nurses and social workers act together to perform screening and subsequent monitoring after implementation of a physical activity program. The team also includes specialists in women’s health in the third level hospital. ICT is used to empower participants, whose adherence is stimulated through the use of a mobile phone-based virtual support group. A basic teaching course is given to facilitate use of technology. The tools used for frailty and cognitive decline screening are being shared with other A3 partners as a result of a collaborative work initiated in 2013 in order to strengthen synergy and harmonisation of databases. Further, the commitment is inserted within the Valencia reference site. Clinical and analytical data are kept in a database while serum and ADN samples are stored in biobank. A parallel basic research programme aims at exploring the effects of lifestyle on genomics of bone metabolism and frailty. The fact that the program is developed within the public health system provides conditions for scalability at national and international level.