Quantified Longevity Guide (QLG)

Quantified Longevity Guide (QLG)

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Activity details

The Israeli Longevity Alliance (ISRLA) promotes cooperation between national and international research institutes, public associations and other bodies acting for the sake of healthy longevity. It promotes the establishment, development and education on appropriate frameworks, services and programs, for the research and treatment of the deteriorative aging process and for healthy longevity. Its flagship projects are: Quantified Longevity Guide(QLG) - seeking to find determinants of Healthy Longevity using information-theoretical health data analysis; and organization of national conferences on healthy longevity.
Action Group:
Objective:
Lead organisation name: 
Israeli Longevity Alliance
Organisation country:
Contact person: 
Ilia Stambler
Contact person email: 
ilia.stambler@gmail.com
Activity type:
Synergy led by:
Start date: 
04/04/2016
End date: 
03/04/2019
Last update: 29/05/2017

Current Status

Ongoing
The methodology of the Quantified Longevity Guide has been validated on available health databases. The results have been published in several scientific papers. Currently, clinical data are sought to proceed toward clinical applications. The results were presented in national conferences in Israel in October 2013, and March 2014, and at the International Conference on Aging and Disease in Beijing, China in November 2014. Some of the published reports include: David Blokh, Ilia Stambler, Estimation of heterogeneity in diagnostic parameters of age-related diseases, Aging and Disease, 5, 218-225, 2014, http://www.aginganddisease.org/EN/10.14336/AD.2014.0500218; David Blokh, Ilia Stambler, Information theoretical analysis of aging as a risk factor for heart disease, Aging and Disease, 6, 196-207, 2015, http://www.aginganddisease.org/EN/10.14336/AD.2014.0623; David Blokh, Ilia Stambler, Applying information theory analysis for the solution of biomedical data processing problems, American Journal of Bioinformatics, 3 (1), 17-29, 2015, http://thescipub.com/abstract/10.3844/ajbsp.2014.17.29. During the commitment report period 04/04/2016-04/02/2017, further research has been conducted as a result of this commitment. During the reported period the commitment has continued to pursue its goals of evaluating the determinants of healthy longevity and predictors of age-related multimorbidity and frailty. The commitment has advocated for the stronger inclusion of biological and physiological markers for the evaluation of frailty, in addition to functional indicators, and for the use of advanced statistical techniques, such as information-theoretical measures, to evaluate weighted and cumulative (synergistic) effects of multiple combined risk factors for age-related frailty, multimorbidity and physiological age. http://www.longevityisrael.org/comorbidity-detection.html. The results of this work, during the reported period, have been presented in the articles: David Blokh, Ilia Stambler, The application of information theory for the research of aging and aging-related diseases, Progress in Neurobiology, S0301-0082(15)30059-9, 2016, doi: http://dx.doi.org/10.1016/j.pneurobio.2016.03.005; David Blokh, Ilia Stambler, The use of information theory for the evaluation of biomarkers of aging and physiological age, Mechanisms of Ageing and Development, S0047-6374(16)30156-7, 2017, doi: http://dx.doi.org/10.1016/j.mad.2017.01.003; Ilia Stambler, Recognizing degenerative aging as a treatable medical condition: methodology and policy, Aging and Disease, 8(5), 2017, http://www.aginganddisease.org/EN/10.14336/AD.2017.0130; Ilia Stambler, Human life extension: opportunities, challenges, and implications for public health policy, in Alexander Vaiserman (Ed.), Anti-aging Drugs: From Basic Research to Clinical Practice, Royal Society of Chemistry, London, 2017, pp. 535-564, http://pubs.rsc.org/en/content/ebook/978-1-78262-435-6#!divbookcontent. The findings were also presented at conferences: Biomedical Innovation for Healthy Longevity -- International Conference, St. Petersburg, Russia, April, 25-28, 2016 (Special panel: Recognizing degenerative aging as a treatable medical condition: methodology and policy); 3rd International Practical Applications for Aging Research Forum at the Basel Life Science Week, Basel, Switzerland, September 21-22, 2016 (Special panel: Current Issues in Aging & Longevity); 2016 International Conference on Aging and Disease (2016 ICAD), Stanford, California, US, October 1-2, 2016 (Special panel: Public support for research of aging and aging-related diseases). Collaboration has been established with the "Shmuel Harofe" Geriatric Medical Center, Beer Yaakov, Israel, to further develop physiological and functional indicators for age-related multimorbidity, frailty and physiological age, in clinical settings. Additional collaboration has been established with the “Vetek” (Seniority) Association (Israel) for the dissemination of the results of this commitment. http://www.longevityisrael.org/

Results

Title Planned Deadline Current Status Category Attachments
Commitment Report for the period 04/04/2016-04/02/2017 - Articles/Conferences 03/02/2017 Achieved Research: Reports (reports, articles, findings) PDF icon a3_commitment_report_-_quantified_longevity_guide_-_ilia_stambler_-_isrla.pdf

Outcomes

No results were indicated for this commitment.