SemanticHealthNet EU funded 'Network of Excellence' will develop a scalable and sustainable pan-European organisational and governance process for the semantic interoperability of clinical and biomedical knowledge, to help ensure that EHR systems are optimised for patient care, public health and clinical research across healthcare systems and institutions. The kick off meeting gathered, in Bonn early January, all consortium members which comprises more than 40 internationally recognised experts, including from USA and Canada, ensuring a global impact. Through a clinically-driven work plan, exemplified in cardiovascular medicine, SemanticHealthNet will capture the needs for evidence-based, patient-centred integrated care and for public health, encapsulating existing European consensus in the management of chronic heart failure and cardiovascular prevention. Experts in EHR architectures, clinical data structures, terminologies and ontology will combine, tailor and pilot their best-of-breed resources in response to the needs articulated by clinicians and public health physicians. SemanticHealthNet will also refer to the SemanticHEALTH and CALLIOPE roadmaps and will link with epSOS II and the eHealth Governance Initiative. The majority of the deliverables will be made public to ensure a wide dissemination of the project's results.