The EU funded project PSIP has developed innovative computer-based applications able to automatically detect situations at risk and to deliver healthcare professionals and patients’ relevant “ad hoc” information helping them to prevent Adverse Drug Events. It has developed tools to search hospital databases and provide reliable numbers about Adverse Drug Events per country, hospital or medical unit, describing their type, consequences and probable causes. To date the prototypes are used routinely in different hospitals. The continuous evaluation of their impact on ADE rates is ongoing and has already provided promising and positive preliminary results.