The EHR IMPACT study, commissioned by the Information Society and Media Directorate General of the European Commission, comprises nine quantitative and two qualitative independent evaluations of good practice cases of interoperable electronic health record (EHR) and ePrescribing systems in Europe and beyond. The goal of the study is to inform and support ongoing initiatives and implementation work by the European Commission, Member State governments, private investors, and other actors. The study aims to improve awareness of the benefits and provide new empirical evidence on the socio-economic impact and lessons learnt from successfully implemented systems.