INTEGRATE promotes a novel IT-based approach aimed at enabling multidisciplinary collaboration in oncology research. This will be achieved through the creation of innovative biomedical infrastructures; emphasis on standards-based harmonization of efforts; the preservation, management and large-scale sharing of multi-level data; and the development of new methodologies and predictive multi-scale models in cancer. The INTEGRATE newsletters will describe aspects of the research problems in focus, inform readers about challenges encountered and progress made towards overcoming them, and refer to relevant project deliverables. We would like to engage our readers in discussions about data sharing and collaboration in the biomedical domain, as well as the scientific issues around information integration and interoperability.