Investigation of aspects related to ICT research in new risk prediction, assessment and management tools for preparation, surveillance, support and intervention in case of largescale adverse health events was one of the main objectives of the European Commission, through the ICT e-health programme, when launching the GAP Project. The GAP Project’s goal is to assess the need and the means for a “generic predictive model” for an ICT system capable to produce health alarms at EU level and design a roadmap for the future research on ICT tools for Guard (Detection), Anticipation and Prediction of potential large scale threats. The Project is focused on four types of risks: Biological (communicable diseases and bioterrorism), Natural, Industrial and Nuclear and Terrorist Risks.