The second epSOS Projectathon took place in Pisa (Italy) from April 11th to 15th, 2011. Parallel to the regular IHE Connectathon, 13 epSOS Participating Nations from Europe and 2 companies took advantage of the chance to test the interoperability of their systems with the goal of exchanging cross-border patient data with other nations using the integration profiles developed by IHE.