This report aims to provide a better understanding of the status quo of the development of eHealth interoperability in Europe, the lessons learned so far and the actions that should be taken in the future to help speed up and facilitate interoperability. It responds to the invitation extended to Member States to report to the European Commission the measures they have taken in relation to the implementation of cross-border interoperability of electronic health record systems. Twenty-two countries provided information on the status of their achievements with regard to eHealth interoperability, and stated their preferences for future activities that should be recommended to go ahead in this domain, either collaboratively among Member States or collectively at European level.