In the future, ICT will offer a growing range of possibilities for modes of health service delivery encompassing communication between patients and healthcare professionals, health literacy, the storage and use of medical data, safety and effectiveness of treatment, location of healthcare service provision as well as cost and efficiency of care2. In addition, advances in medical science and medical technology will provide new possibilities for prevention and care. This report reviews eHealth-related initiatives implemented throughout the European Union (EU) at the local and regional level, with a focus on the role played within these initiatives by local and regional authorities (LRAs) and other relevant actors. The aim of the review is to provide an understanding of most common initiatives promoted at the territorial level, highlighting those creating value and sustainable solutions and, accordingly, drawing conclusions about how these interventions may be further supported and facilitated at EU level.