For any healthcare systems, chronic diseases represent the heaviest cost burden. A plethora of ICT based applications have been developed in recent years, allowing a partial tackling of problems related to specific diseases. CLEAR proposes the implementation of a tele-rehabilitation service in four European Member States (IT, ES, NL, PL). The ambition is to convert the project, after its completion, to a European service for tele-rehabilitation and to contribute to the harmonization of e-health services in the EU.