Nine European regions have teamed up to run one of the largest ever telemedicine trials, the Renewing Health large-scale pilot project. By February 1, 2011, all regions will have gone live. The aim is to generate data for European healthcare systems so that telemedicine can be adopted as part of regular care for chronically ill patients. Renewing Health is a highly ambitious clinical trial that will involve close to 8,000 patients in the intervention groups with cardiovascular disease, chronic obstructive pulmonary disease or diabetes from nine regions in different parts of Europe.