To provide strong support for both the European Union Virtual Physiological Human (VPH) research initiative and the global "Physiome" community, the process to establish a European VPH Institute has now officially started. The idea to establish a VPH Institute dates back to the STEP VPH Research roadmap where it was suggested to establish a European Institute dedicated entirely to the Virtual Physiological Human (VPH). This idea has been re-proposed and expanded in the recent "Vision & Strategy" document of the VPH Network of Excellence, and has received overwhelmingly positive reaction by the research community, with nearly 300 signatures from over 30 countries. The Pro Tempore Board of Directors has now formally entered the formation process, which should be completed before the end of 2010.