To prepare for the large scale deployment of eHealth services under the Connecting Europe Facility (CEF), this workshop explored different business models supporting European-wide eHealth services. This requires to also examine the need for ensuring cross-border connectivity, i.e. to consider all layers of interoperability (functional, semantic and technical) in order to facilitate such services. Discussions started from the Smart Open Services for European Patients (epSOS) experience and explore future opportunities to build on this. In order to enable cross-organisational & cross-border information flows for further clinical needs/scenarios such as chronic disease management (e.g. a chronic disease tailored summary) was addressed by SemanticHealthNet. All presentations are now online under the Agenda.