Hosted by the Government of Botswana through the Department of Research, Science and Technology, supported by the European Commission and African Union Commission and Technical Co-Sponsored by IEEE, IST-Africa 2011 will take place in Gaborone, 04 – 06 May 2011. Part of the IST-Africa Initiative, which is supported by the European Commission under the ICT Theme of Framework Programme 7 (FP7), IST-Africa 2011 is the sixth in an Annual Conference Series which brings together senior representatives from leading commercial, government & research organisations across Africa and from Europe, to bridge the Digital Divide by sharing knowledge, experience, lessons learnt and good practice and discussing policy related issues. IST-Africa 2011 is focused on applied ICT and the core thematic areas include: eHealth; eInfrastructures; Technology Enhanced Learning and ICT Skills; Digital Libraries and Intelligent Content; Living Labs; Open Source Software; ICT for eInclusion and eAccessibility; ICT for Environmental Sustainability; RFID and Networked Enterprise; Cloud Computing; eGovernment & eDemocracy; Networked Media; Transformation of Research Results into Local Innovation; IPv6.