To install DomiSMP 5.0, the system must have a supported Java Runtime Environment, either version 8 or 11. It also requires a supported database management system such as MySQL 8.0.x or Oracle 11g/19c, as well as an application server like Tomcat 9.x or WebLogic 12.2.x. Additional resources, including binaries and database scripts, can be obtained from the setup package.