This publication presents the EU Strategy for the Danube Region (EUSDR) focusing efforts on the specific needs and characteristics of the region, for example through Europe’s research and innovation policies. It can act as a major building block for the implementation of Europe 2020. In the Danube region, which hosts the most international river basin in the world, linking 14 countries and 115 million people, the Strategy provides specific opportunities. These include smarter transport links, cheaper and more secure energy through better connections, and co-operation to minimise environmental risks and disasters. The EUSDR encourages innovative solutions in all these areas. In addition, the strategy contains a specific priority area which addresses the potential of the knowledge society in the region.