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Rapid antibiotic detection for illegal and unlicenced substances in animal feedingstuffs

Contract nr: QLK5-CT-1999-30900
Project type: RS (Research and Technological Development Project)
Starting date: 01-10-2000
Duration: 42 months
Total cost: 1,338,352 EUR
EC Contribution: 1,076,843 EUR
Scientific Officer: Michel VAN DEN BOSSCHE
Research topic: 5.1.1. Sustainable agriculture/Animal Systems

Abstract:
In the EU, human health concerns have resulted in the antibiotic growth promoters avoparcin, spiramycin, tylosin, virginiamycin and zinc bacitracin being banned from use in animal feedingstuffs. Existing "Community methods of analysis" are microbiologically based, non-specific, susceptible to feed component interference and unsuitable for effective policing of the ban. New screening and confirmatory tests are required. Firstly, immunoassay dipstick tests will be developed. Using the novel idea of antiidiotype monoclonal antisera as surrogate ligands, carbon labelled monoclonal antisera, raised to each drug, will be employed in a competitive assay format resulting in robust, reliable and highly specific assays, less susceptible to interference than previous immuno- or microbiological assays. Secondly, mass spectrometric confirmatory techniques will be developed, allowing unequivocal identification/quantification of each antibiotic. Collaborative testing will establish their usefulness as definitive EU methods of analysis. This twin-track approach will facilitate the effective implementation of EU policy.


Coordinator
David WEIR
The Queen's University of Belfast
Belfast
UNITED KINGDOM
Tel.: +44 2890 274067
Fax: +44 2890 687558
E-mail: d.weir@aub.ac.uk


Partners
  Boaz AVRON
Weizmann Institute of Science
Rehovot
ISRAEL
Tel.: +972 8 9343995
Fax: +972 8 9344165
E-mail: boaz.avron@weizmann.ac.il
  Piet VAN WICHEN
EURO-Diagnostica B.V.
Arnhem
THE NETHERLANDS
Tel.: +31 263630364
Fax: +31 263645111
  Henk J. HUIZING
Agrotechnological Research Institute
Wageningen
THE NETHERLANDS
Tel.: +31 317475023
Fax: +31 317475347
E-mail: h.j.huizing@ato.wag-ur.nl
  Jacques WILLEMS
University of Ghent
Gent
BELGIUM
Tel.: +32 9 264 30 29
Fax: +32 9 264 35 83
E-mail: nathalie.vandepitte@rug.ac.be
  Klass VAN 'T RIET
Nederlandse Organisatie voor Toegepast Wetenschappelijk Onderzoek
Zeist
THE NETHERLANDS
Tel.: +31 306944965
Fax: +31 306944192
E-mail: vantRiet@voeding.tno.nl