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Cloning and functional analysis of fish peroxisome proliferator-activated receptors: the transcriptional control of lipid metabolism in farmed fish species

Contract nr: QLK5-CT-1999-30360
Project type: RS (Research and Technological Development Project)
Starting date: 01-12-2000
Duration: 36 months
Total cost: 868,426 EUR
EC Contribution: 824,975 EUR
Scientific Officer: Dominique LEVIEIL
Research topic: 5.1.2. Sustainable fisheries and aquaculture

Abstract:
Among the major problems encountered in intensive fish aquaculture, the accumulation of fat in the tissues of farmed fish and the dependency of the aquaculture industry on fish oils for high-quality feeds are issues of exceptional economic interest. The above problems can be efficiently addressed only by an increased understanding of the processes involved in lipid homeostasis in fish. In the work proposed herein, this is to be accomplished through the cloning and functional analysis of fish peroxisome prolifirator-activated receptors (PPARs). PPARs are lipid-activable transcription factors that regulate both arms of lipid homeostasis in higher vertebrates. This study intends to provide the scientific background necessary for innovative solutions to the lipid metabilism-associated problems encountered in aquaculture, and thus to contribute towards the sustainability of the industry.


Coordinator
Grigorios KREY
National Agricultural Research Foundation - Fisheries Research Institute
Kavala
GREECE
Tel.: +30 59422691
Fax: +30 59422222
E-mail: fri@otenet.gr


Partners
  Douglas TOCHER
University of Stirling
Stirling
UNITED KINGDOM
Tel.: +44 1786 467996
Fax: +44 1786 472133
E-mail: dtr1@stir.ac.uk
  Jose M. BAUTISTA
Universidad Complutense de Madrid
Madrid
SPAIN
Tel.: +34 913943827
Fax: +34 913943824
E-mail: bauchem@eucmax.sim.ucm.es
  Alex OBACH
Nutreco Aquaculture Research Centre AS
Stavanger
NORWAY
Tel.: +47 51825516
Fax: +47 51825501
E-mail: alex.obach@nutreco.com
  Guillermo BORES SALADICH
Cria de Pescado S.A.
L'Ametila de Mar (Tarragona)
SPAIN
Tel.: +34 977493720
Fax: +34 977493721
E-mail: cripesa@teleline.es