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The effect of olive oil consumption on oxidative damage
in European populations
EUROLIVE

Contract number : QLK1-2001-00287
Contract type : Shared Cost Project
Total cost : € 2.671.988
EC contribution : € 1.895.661
Starting date : 1/01/2002
Duration : 36 Months
Scientific Officer : Antonio di Giulio
Project website : not yet available
Coordinator
Dr María Isabel Covas
Institut Municipal d'Investigació Mèdica
Lipids and Cardiovascular Epidemiology Research Unit
Doctor Aiguader 80
08003 Barcelona
Spain Tel.: +34932211009
Fax: +34932213237
E-mail: mcovas @ imim.es
Background

EUROLIVE is a European multi-centre clinical nutritional trial concerning the effect of a traditional Mediterranean antioxidant-rich food, olive oil, on oxidative stress and damage to lipids and DNA in humans. EUROLIVE also aims at studying the bioavailability and the binding of olive oil phenolics compounds to low-density lipoproteins. Our study will focus on whether a reasonable supplemental amount of refined (without phenolics), common (with low phenolic content) and extra virgin (with high phenolic content) olive oil would reduce lipid peroxidation and DNA oxidation in 180 humans from 3 European populations (Northern, Central and Southern), and whether there are differences on the effects according to the olive-oil phenolic concentration. The market prices of olive oil differs being refined and common olive oil cheaper than virgin olive oil.

Objectives
  • To compare the impact of olive oil, and antioxidant-rich foodstuff, on oxidative damage and low-density lipoprotein (LDL) fatty acid composition across selected European countries.
  • To investigate the bioavailability of olive oil phenolic compounds in humans.
  • To determinate the relation between olive oil ingestion and the binding of phenolic compounds to LDL.
  • To explore differences among healthy men from different European areas in lipid peroxidation and fatty acid composition of LDL.
  • To determine whether addition or substitution of monounsaturated fat results in better LDL fatty acid composition after three monts of olive oil administration in Central and Northern European participants.
(expected) Results and achievements

Milestones; consortium agreement signature and meetings; common protocol and instruments to determine basal variables (non-laboratory data). Olive oil analyses. Bioavailability and clinical trials complexion. Laboratory measurements complexion. Common edited data base. Scientific manuscripts. Dissemination manuscript for European consumers. We expect to observe differences in the impact of olive oil consumption on oxidative damage across European areas and to deliver accurate recommendations for olive oil consumption.


Partners

Copenhagen University Hospital
Department of Clinical Pharmacology
20 Tagensvej
2200 Copenhagen
Denmark
University of Kuopio
Research Institute of Public Health
Harjulantie 1 B
PO Box 1627
70211 Kuopio
Finland
Università degli Studi di Bologna
Dipartimento di Medicina Clinica E Biotecnologia Applicata
Centro Aterosclerosi 'GC Descovich'
Via Massarenti, 9
40138 Bologna
Italy
Deutsches Institut für Ernährungsforschung
Abteilung für Interventionsstudien
Arthur-Scheunert-Allee 114-116
14558 Bergholz-Rehbrücke
Germany
Universität zu Berlin
Institute of Transfusion Medicine
Campus Charité Mitte
Schumannstraße 20/21
10117 Berlin
Germany
Universitat de Barcelona
Department de Nutrició i Bromatologia
Avda. Joan XXIII S/N
Facultat de Farmacia
08028 Barcelona
Spain
Oy Jurilab Ltd
Neulaniementie 2 L 12
70210 Kuopio
Finland
KEPKA
Consumer protection center
54, Tsimiski St.
54623 Thessaloniki
Greece


Fifth Framework Programme

PDF Version

:

Volume 1 (PDF 2.9 MB)

   

Volume 2 (PDF 1.9 MB)

 

Last update

:

23-09-2003



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