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The role of lipids in neurodegeneration and their preventive potential in diet
LIPIDIET

Contract number : QLK1-2001-00172
Contract type : Shared Cost Project
Total cost : € 2.888.035
EC contribution : € 2.208.750
Starting date : 1/01/2002
Duration : 36 Months
Scientific Officer : Antonio di Giulio
Project website : not yet available
Coordinator
Dr Tobias Hartmann
University of Heidelberg
Zentrum für Molekulare Biologie Heidelberg
INF 282
69120 Heidelberg
Germany
Tel.: +49 6221 546844
Fax: +49 6221 545891
E-mail: tobias.hartmann @ zmbh.uni-heidelberg.de
Background

To prevent and treat age associated neurodegenerative diseases is a key challenge of this century. Based on recent findings it is promising to develop dietary lipid related disease prevention strategies. The present project will undertake this strategic approach which will first be applied to Alzheimer's disease, in which brain lipids are believed to play an important role. Three converging lines of investigation will be pursued. In vitro studies of the role of lipids in neuronal degeneration and of the effects thereon of distinct lipid related treatments will be preformed first. The resulting promising treatments will than be used for the preparation of formulations whose effectiveness will be tested in vivo utilising distinct models of neurodegeneration and dementia. The best diets will be tested in man for their ability to halt and prevent disease.

Objectives

The objective of this proposal is to develop and evaluate lipid diets and related food additives for their preventive and treatment-related beneficial effects on age related brain neurodegeneration and Alzheimer disease (AD). This will be done by experiments directed at this complementary and interrelated lines of investigation:

  • Cellular and molecular studies of the role of lipids in brain neurodegeneration and effects of distinct lipid related treatments on neuronal function;
  • Formulation of promising lipid related treatments and assessment, utilising in vivo models of brain neurodegeneration and AD, of their bioavailability and effectiveness;
  • Lipid diet studies in man, to slow down and eventually prevent disease. The chronic nature of neurodegeneration and bioavailibility render this lipid diet approach particularly promising.
(expected) Results and achievements

Lipid modulation of APP, Aß and PS processing. Epidemiological results on early cholesterol levels, dietary habits for later in life diseases, pharmacokinetics of 20 lipid treatments, electrophysiology, 5 diets for in vivo use with preventive potential, ApoE3 and ApoE4 effects, in vivo effects, safety, influence on peripheral lipid metabolism, neurological preventive diet, dietary advice.


Partners

Tel Aviv University
Dept. of Neurobiochemistry
Faculty of Life Sciences
Ramat Aviv, PO Box 39040
69978 Tel Aviv
Israel
University Szeged
Dept. of Medical Chemistry
Dom Ter 8.
6723 Szeged
Hungary
Université de Genève
Pharmacologie Centre Medical Universitaire
Rue Michel-Servet 1
1211 Genève 4
Switzerland
Czech Academy of Sciences
Institute of Physiology
Department of Neurochemistry
Videnska 1083
14220 Prague, 4
Czech Republic
University of Kuopio
Department of Neurosciences and Neurology
Harjulantie 1
PO Box 1627
70211 Kuopio
Finland
Numico Research B.V.
Bosrandweg 20
PO Box 7005
6700 CA Wageningen
The Netherlands


Fifth Framework Programme

PDF Version

:

Volume 1 (PDF 2.9 MB)

   

Volume 2 (PDF 1.9 MB)

 

Last update

:

23-09-2003



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