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Optimal nutrition towards osteoporosis prevention:
Impact of diet and gene-nutrient interactions on calcium and bone metabolism
OSTEODIET

Contract number : QLK1-1999-00752
Contract type : Shared Cost Project
Total cost : € 2.044.608
EC contribution : € 1.454.063
Starting date : 1/02/2000
Duration : 36 Months
Scientific Officer : Rosanna d'Amario
Project website :
http://osteodiet.ucc.ie
Coordinator
Prof. Dr Kevin Cashman
University College Cork
Nutritional Sciences
Department of Food Science, Food Technology and Nutrition
Western Road
Cork
Ireland
Tel.: +353-21-4902883
Fax: +353-21-4270244
E-mail: k.cashman @ ucc.ie
Background

The overall objective is to investigate the influence of diet, and its interaction with individual genetic variation, on the metabolism of calcium and bone in postmenopausal women in order to reinforce the scientific base for dietary strategies for osteoporosis prevention in Europe. The project will apply state of the art techniques in human studies to investigate how diet (Na, Ca, protein, vitamin K) and individual genetic variation (genes for vitamin D receptor, Apolipoprotein E) influence metabolic processes of Ca and bone. Four dietary intervention studies will be carried out in postmenopausal women. One of those will also develop and evaluate a novel radio- tracer method for bone loss measurement in intervention studies in humans. Those studies will provide new information on the role of diet and genetic variability in the mechanism of development of osteoporosis and on how dietary strategies may be developed for its prevention.

Objectives

Overall objective: To investigate the influence of diet, and its interaction with individual genetic variation, on the metabolism of calcium and bone in postmenopausal women in order to reinforce the scientific base for dietary strategies for osteoporosis prevention in Europe.

Specific objectives:

  • To determine the effect of a high salt (sodium) diet on metabolism of calcium and bone and how it is influenced by the level of dietary calcium.
  • To investigate the effect of individual genetic variation (vitamin D receptor gene) on the adaptive response of calcium and bone metabolism to a calciuric (high sodium-high protein) diet.
  • To determine the effect of dietary intake of vitamin K on the metabolism of calcium and bone and how it is influenced by individual genetic variation (apolipoprotein E gene).
  • To develop and evaluate a novel radio-tracer (41Ca) method for assessing the impact of diet on bone resorption (loss) and calcium metabolism.
(expected) Results and achievements

New scientific information on the influence of (i) diet (salt, calcium, protein, vitamin K) and (ii) individual genetic variation on bone integrity and on mechanisms of development of osteoporosis Reinforced scientific base for the development of nutrition strategies, policies and guidelines. Community action programmes and new food products for osteoporosis prevention in Europe. Novel radiotracer method for measurement of bone loss and calcium metabolism in intervention studies in humans. The project will also will contribute to the evolution of EU policy on public health, including women's health, and ageing the attainment of EU social objectives e.g. improvement of the health and quality of life for consumers. The scientific base for improving the quality (particularly the nutritional quality) of food products in response to consumer demands. Will also provide excellent opportunities for the training of European postgraduates and post-doctoral scientists to achieve a high level of expertise in the area of food.


Partners

Institute of Food Research
Diet Health & Consumer Science Division
Norwich Research Park, Colney
NR4 7UA Norwich
United Kingdom
Royal Veterinary and Agricultural University
Research Department of Human Nutrition
Rolighedsvej 30
1958 Frederiksberg C
Denmark
Swiss Federal Institute of Technology
Zürich Laboratory for Human Nutrition
Institute of Food Science
Seestraße 72
PO Box 474
8803 Rüschlikon
Switzerland
ETH Zürich
Laboratory of Particle Physics
ETH Hönggerberg Building HPK
8093 Zürich
Switzerland
Johannes Gutenberg-Universität Mainz
Institut für Kernchemie
Institut für Physik
Fritz Strassmann Weg 2
55099 Mainz
Germany
The Danish Veterinary and Food Administration
Institute for Food Research and Nutrition
Mørkhøj Bygade 19
2860 Søborg
Denmark


Fifth Framework Programme

PDF Version

:

Volume 1 (PDF 2.9 MB)

   

Volume 2 (PDF 1.9 MB)

 

Last update

:

23-09-2003



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