The overall objective is to investigate the influence of diet, and its interaction with individual genetic variation, on the metabolism of calcium and bone in postmenopausal women in order to reinforce the scientific base for dietary strategies for osteoporosis prevention in Europe. The project will apply state of the art techniques in human studies to investigate how diet (Na, Ca, protein, vitamin K) and individual genetic variation (genes for vitamin D receptor, Apolipoprotein E) influence metabolic processes of Ca and bone. Four dietary intervention studies will be carried out in postmenopausal women. One of those will also develop and evaluate a novel radio- tracer method for bone loss measurement in intervention studies in humans. Those studies will provide new information on the role of diet and genetic variability in the mechanism of development of osteoporosis and on how dietary strategies may be developed for its prevention.
Overall objective: To investigate the influence of diet, and its interaction with individual genetic variation, on the metabolism of calcium and bone in postmenopausal women in order to reinforce the scientific base for dietary strategies for osteoporosis prevention in Europe.
- To determine the effect of a high salt (sodium) diet on metabolism of calcium and bone and how it is influenced by the level of dietary calcium.
- To investigate the effect of individual genetic variation (vitamin D receptor gene) on the adaptive response of calcium and bone metabolism to a calciuric (high sodium-high protein) diet.
- To determine the effect of dietary intake of vitamin K on the metabolism of calcium and bone and how it is influenced by individual genetic variation (apolipoprotein E gene).
- To develop and evaluate a novel radio-tracer (41Ca) method for assessing the impact of diet on bone resorption (loss) and calcium metabolism.
New scientific information on the influence of (i) diet (salt, calcium, protein, vitamin K) and (ii) individual genetic variation on bone integrity and on mechanisms of development of osteoporosis Reinforced scientific base for the development of nutrition strategies, policies and guidelines. Community action programmes and new food products for osteoporosis prevention in Europe. Novel radiotracer method for measurement of bone loss and calcium metabolism in intervention studies in humans. The project will also will contribute to the evolution of EU policy on public health, including women's health, and ageing the attainment of EU social objectives e.g. improvement of the health and quality of life for consumers. The scientific base for improving the quality (particularly the nutritional quality) of food products in response to consumer demands. Will also provide excellent opportunities for the training of European postgraduates and post-doctoral scientists to achieve a high level of expertise in the area of food.