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Health implications of natural non-nutrient antioxidants (polyphenols):
Bioavailability and colon carcinogenesis
POLYBIND

Contract number : QLK1-1999-00505
Contract type : Shared Cost Project
Total cost : € 3.481.810
EC contribution : € 2.310.407
Starting date : 1/01/2000
Duration : 36 Months
Scientific Officer : Rosanna d'Amario
Project website : not yet available
Coordinator
Dr Ian Johnson
Institute of Food Research
Diet, Health and Consumer Sciences Division
Norwich Research Park, Colney
NR4 7UA Norwich
United Kingdom
Tel.: +44-1603-255000
Fax: +44-1603-507723
E-mail: gary.williamson @ bbsrc.ac.uk
Background

Colon cancer kills approximately 75000 Europeans per year and even a modest reduction would significantly benefit the EU both socially and financially. Many studies show an effect of naturally-occurring dietary plant polyphenols (non- nutrient antioxidants) on carcinogenesis. There are large differences in consumption of amount and type of polyphenols between North and South with lower risks associated with the Mediterranean diet. We will obtain urgently-needed data to permit a risk-benefit analysis of the significance of dietary polyphenols in the modulation of colon cancer, and whether there might be justification for dietary modification, the production of supplements and novel foods.

Objectives

We will study the effect of polyphenols on health indicators: uptake and metabolism, influence on carcinogen metabolism, effect on cell proliferation and colon carcinogenesis. Structure-function and dose-response studies will be conducted by combining molecular, cellular and in vivo experimental systems with suitable biomarkers of exposure and effect. By these means we will obtain urgently needed data to permit a risk-benefit analysis of the significance of dietary polyphenols in the modulation of colon cancer, and whether there might be a justification for dietary modification, the production of supplements, or novel foods, etc.

The objectives are to answer the following most important questions identified in these programmes:

  • How are dietary polyphenols metabolised?
  • How do polyphenols alter the rates of carcinogen metabolism?
  • What are the mechanisms whereby polyphenols affect cell signalling involved in apoptosis and proliferation?
  • How do polyphenols modulate early events of colon carcinogenesis?

Partners

Department of Preclinical and Clinical Pharmacology
Viale Pieraccini 6
50139 Florence
Italy
INRA
Unité de Recherche Biopolymères et Arômes.
2, Place Viala
34060 Montpellier Cedex
France
The University of Surrey
School of Biological Sciences
GU2 5XH Guildford, Surrey
United Kingdom
Centre for Plant Breeding and Reproduction Research
Droevendaalesteeg 1
PO Box P.0. Box 16
6708 PB Wageningen
The Netherlands
Université Claude Bernard Lyon 1
Laboratoire des Produits Naturels
Upresa CNRS 5013
43 Boulevard du 11 Novembre 1918
Bât. 303
69622 Villeurbanne
France
Unilever UK Central Resources
Unilever Research, Colworth House
Sharnbrook
MK44 LLQ Bedford
United Kingdom
Technical Research Center of Finland
VTT Biotechnology and Food Research
Tietotie 2
PO Box 1500
02044 VTT Espoo
Finland
Universidad de Salamanca
Dpt. Química Analítica, Nutrición y Bromatología
Facultad de Farmacia
Campus "Miguel de Unamuno"
37007 Salamanca
Spain
RIKILT-DLO
Food Health and Food Safety Dept.
Bornsesteeg 45
PO Box 230
6708 PD Wageningen
The Netherlands
Université des Sciences et Technologies de Lille
Laboratoire de Chimie Organique et Macromoléculaire
UPRESA 8009
Cité Scientifique 1
Bâtiment C4
59655 Villeneuve d'Ascq
France
Societé Française de Distilleries
PO Box BP 47
07150 Vallon Pont d'Arc
France
Università degli Studi di Siena
Istituto di Scienze Farmacologiche
Via E.S. Piccolomini, 170
53100 Siena
Italy
Mars UK Ltd
Dundee Road
SL1 4JX Slough
United Kingdom


Fifth Framework Programme

PDF Version

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Volume 1 (PDF 2.9 MB)

   

Volume 2 (PDF 1.9 MB)

 

Last update

:

23-09-2003



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