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Cord blood as an allogeneic source of stem cell for clinical use

   
Project

QLK3-1999-00380

Cell factory area

3.1.1

EU Contribution

1 400 000 Euro

Duration

36 months

Type

Thematic Network

Starting date

01-01-2000

Keywords
cord blood cells
hematopoietic stem cells (HSC)
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ABSTRACT
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Cord blood cells, collected at birth, have new interesting properties which can be used for treatment of leukemias and other malignant diseases and also for the treatment of genetic or acquired hematological disorders. Cord blood banks have been established worldwide, and thanks to international collaboration, results of allogeneic unrelated cord blood transplants have been analysed. From these studies, it can be concluded that this new source of hematopoietic stem cells is a life-saving therapy used in a large variety of potentially fatal diseases mostly in children. The objectives of this proposal are to better characterise hematopoietic stem cells present in cord blood and take advantage of the immaturity and proliferative characteristics of the cells to treat a large variety of malignant, immunological, genetic and infectious diseases. The proposal will be divided into four components: hematopoiesis, immunology, clinical applications of cord blood cells and interface between transplant centres and cord blood banks.

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CONSORTIUM
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COORDINATOR
  Prof. Eliane Gluckman
Bone Marrow Unit
Hôpital-Saint-Louis
1 Avenue Claude Vellefaux
75475 Paris Cedex 10, France
Tel: +33 142499644
Fax: +33 142499634
eliane.gluckman@chu-stlouis.fr

PARTNERS
  Prof. William Arcese
University "La Sapienza"
Institute of Hematology
Via Benevento 6
00161 Roma, Italy
Tel: +39 685795116
Fax: +39 685795293
arcese@bce.med.uniroma1.it

Prof. Dominique Charron
HLA et Medecine
Lab. Immunogenetique
Institut des Cordeliers
15, rue de l'Ecole de Médecine
75006 Paris, France
Tel: +33 140460358
Fax: +33 143267613
charron@ccr.jussieu.fr

Prof. Manuel Fernandez
University Hospital Clinica Puerta de Hierro
San Martin de Porres 4
28035 Madrid, Spain
Tel: +34 13162240
Fax: +34 13730535
mnf@hematol.cph.es

Prof. Willem Fibbe
Eurocord Nederland Foundation
Leiden University Hospital
Albinusdreef 2
2300 RC Leiden, The Netherlands
Tel: +31 715262271
Fax: +31 715266755
wfibbe@hematology.azl.nl

Prof. Joan Garcia
Fundacio Privada
Institut de Recerca Oncologia
Autovia Castelldefels KM2, 7
08907 Barcelona, Spain
Tel: +34 932633817
Fax: +34 932607776
jgarcia@iro.es

Prof. Alejandro Madrigal
Anthony Nolan Bone Marrow Trust
The Royal Free Hospital
Pond Street, Hampstead
NW3 2QG London, United Kingdom
Tel: +44 1712848311
Fax: +44 1712848301
madrigal@rfhsm.ac.uk

Prof. Girolamo Sirchia
Ospedale Maggiore
IRCCS
Milano Cord Blood Bank
Via Francesco Sforza, 35
20122 Milano, Italy
Tel: +39 25451431
Fax: +39 25458129
gsirchia@polic.cilea.it

Prof. Peter Wernet
Bone Marrow Donor Center
Heinrich Heine University
Bldg. 14.80, Moorenstr. 5
40001 Duesseldorf, Germany
Tel: +49 2118119147
Fax: +49 2118119147
peter.wernet@uni-duesseldorf.de

Prof. Franco Locatelli
IRCCS Policlinico San Matteo
Clinica Pediatrica
Unversita di Pavia
Piazzale Golgi 2
27100 Pavia, Italy
Tel: +39 382502607
Fax: +39 382527976
f.locatelli@smatteo.pv.it

Dr. Bruno Peault
Inserm Unité 506
Ontogénie des cellules sanguines
12, avenue Paul Vaillant-Couturier
94807 Villejuif, France
Tel: +33 145595263
Fax: +33 145595261
peault@infobiogene.fr
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