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Glycosylation engineering for novel antibiotics

   
Project

QLK3-1999-00095

Cell factory area

3.1.1

EU Contribution

1 832 606 Euro

Duration

36 months

Type

Research project

Starting date

01-02-2000

Keywords
actinomycete bacteria
polyketide antibiotics
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ABSTRACT
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Most of the antibiotics in clinical use are produced by actinomycete bacteria. The polyketides in particular are a structurally diverse group of antibiotics, which include compounds with antibacterial, anti-fungal and other bioactivities. Their diversity is further increased by the attachment of sugar residues, which have a decisive influence on bioactivity. The continuing problem of microbial resistance to existing antibiotics means that there is an urgent need to use information about these biosynthetic pathways in actinomycetes to accelerate the production of new antibiotic compounds. Fortunately, even small structural changes may provide significant therapeutic gains. The objectives of this project are to use a range of both in vivo and in vitro approaches to produce polyketide antibiotics bearing altered sugar residues.

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CONSORTIUM
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COORDINATOR
  Dr. Peter Leadlay
The Chancellor, Masters and Scholars
of the University of Cambridge
Department of Biochemistry
80 Tennis Court Road
CB2 1GA Cambridge, United Kingdom
Tel: +44 1223333656
Fax: +44 1223766091
pfl10@mole.bio.cam.ac.uk

PARTNERS
  Dr. Andreas Bechthold
Eberhard-Karls-Universität Tübingen Pharmazeutische Biologie
Pharmazeutisches Institut
Auf der Morgenstelle 8
Wilhelmstraße 7
72074 Tübingen, Germany
Tel: +49 70712975483
Fax: +49 7071295250
bechthold@uni-tuebingen.de

Prof. Wolfgang Piepersberg
Bergische Universität-Gesamtochschule Wuppertal
GH, FB 9 - Chemische Mikrobiologie
Gauss-Str. 20
42097 Wuppertal, Germany
Tel: +49 2024392521
Fax: +49 2024392698
piepersb@uni-wuppertal.de

Dr. Barrie Wilkinson
Glaxo Research and Development Limited
Glaxo Wellcome House
Berkeley Avenue
Medicines Research Center
Greenford, UB6 0NN Middlesex, United Kingdom
Tel: +44 1438763781
Fax: +44 1438764473
bw37730@glaxowellcome.co.uk

Dr. Lothar Elling
Institut für Enzymtechnologie der Heinrich-Heine Universität Düsseldorf
Universitätsstraße 1
40225 Düsseldorf, Germany
Tel: +49 2461613348
Fax: +49 2461612490
l.elling@fz-juelich.de

Dr. Patrick Caffrey
Department of Industrial Microbiology
University College Dublin
Stillorgan Road
Belfield, Dublin 4, Ireland
Tel: +35 317061396
Fax: +35 317061183
patrick.caffrey@ucd.ie

Prof. Jose A. Salas
Universidad de Oviedo
San Francisco S/N
33006 Oviedo, Spain
Tel: +34 985103652
Fax: +34 985103652
jasf@sauron.quimica.uniovi.es

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