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Brussels, 27 October, 1998

European Commission coordinates
TSE research launched following mad cow crisis.
(Symposium on transmissible spongiform encephalopathies)

Keywords: Transmissible Spongiform Encephalopathies (TSE); mad cow crisis

Researchers involved in 30 projects supported by the "European initiative on transmissible spongiform encephalopaties" action plan are meeting in Brussels on 27-28 October, to present their projects, exchange information and assess potential outcome. Mrs Cresson, Commissioner responsible for research, innovation, education, training and youth, will open the symposium.

In response to the so-called “mad cow” crisis, the Commission launched the “European initiative on transmissible spongiform encephalopathies (TSE)" action plan. This major initiative was rapidly launched as a result of intense co-operation throughout the Commission services and among Member States, and after the European Parliament and Council allowed supplementary funding matching the perceived challenges.

Since 1996, three calls for proposals on TSE were launched (one specific call within the FAIR programme and two joint calls within the three life sciences programmes, namely FAIR, Biomed and Biotech).

As a result 30 projects have been funded and are now underway; a final batch of 13 projects is currently under negotiation and will complement the ongoing research activities. It is now time to assess the potential outcome of the various. For this reason, the Commission is organising a TSE research symposium with all co-ordinators of the currently funded projects (see below for list of projects).

The Commission feels that this will provide important opportunities for fruitful interactions and possibly further collaborations, for instance in the identification of disease-causing agents, diagnostics, inactivation procedures, therapeutic approaches.

The symposium will be opened by Mrs Cresson, Commissioner responsible for research, innovation, education, training and youth, and will be attended by relevant Commission services, Scientific Committees and representative of the Member States.

For further information, please contact:

Etienne Magnien
Head of unit, Biotechnology, DG XII
Fax: +32-2-299.18.60

Umberto Bertazzoni
Head of unit, Biomedecine and Health, DG XII
Fax: +32-2-295.53.65

Liam Breslin
Head of unit, f.f., FAIR, DG XII
Fax: +32-2-296.43.22

Jacques Burtin
Head of unit, Agriculture, DG VI
Fax: +32-2-295.03.29

Michel Claessens
Communication Unit, DG XII
Fax: +32-2-295.82.20
E-mail: michel.claessens@ec.europa.eu


Projects supported by the "European initiative on transmissible spongiform encephalopaties" (TSE) action plan.

EUROPEAN CENTRALIZED FACILITY FOR HUMAN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (PRION DISEASES), HERBERT BUDKA, LINISCHES INSTITUT FÜR NEUROLOGIE DER, UNIVERSITAT WIEN (AT), (Tel:+431404005501, Fax: +431404005511, E-Mail: H.BUDKA@AKH-WIEN.AC.AT)

TRANSGENIC MICE EXPRESSING HUMAN PRION PROTEIN USE FOR CHARACTERISATION OF HUMAN ENCEPHALOPATHIES, AND SENSITIVITY FOR DETECTION OF INFECTIVITY, JEAN-JACQUES HAUW, ASSOCIATION CLAUDE BERNARD POUR LE DEVELOPPEMENT DES RECHERCHES BIOLOGIQUES ET MEDICALES DANS LES (FR), Tel: +33142161881, Fax: +33144239828, E-Mail: DANIELLE.SEILHEAN@PSL.A)

INVESTIGATION OF PUTATIVE SIGNALTRANSDUCTION PROCESSES OF NORMAL PRION PROTEIN AND THEIR ROLE IN SPONGIFORM ENCEPHALOPATHY PATHOGENESIS, BRIAN H ANDERTON, INSTITUTE OF PSYCHIATRY (UK), (Tel: +44-171-9193258, Fax:+441717080017, E-Mail: B.ANDERTON@IOP.BPMF.AC.UK)

IN VITRO INVESTIGATION OF PRP-INDUCED NEURODEGENERATION: DEVELOPMENT OF A SYSTEM FOR TESTING POTENTIAL THERAPEUTIC AGENTS, ALUN WILLIAMS, UNIVERSITY OF GLASGOW (UK), (Tel: +441413305773, Fax: +441413305602)

PRPSC DISTRIBUTION AND KINETICS IN LYMPHOID TISSUES OF SHEEP WITH NATURAL SCRAPIE: EFFECTS OF SHEEP PRP GENOTYPE AND SCRAPIE STRAINS, LUCIEN VAN KEULEN, DLO INSTITUTE FOR ANIMAL SCIENCE AND HEALTH (NL), (Tel:+31320238393, Fax: +31320238050, E-Mail: L.J.M.VANKEULEN@ID.DLO.NL)

ROLE OF PRP IN PRION SPREAD AND ESTABLISHMENT OF CENTRAL NERVOUS SYSTEM INFECTION, DOMINIQUE DORMONT, COMMISSARIAT A L'ENERGIE ATOMIQUE (FR), (Tel: +33146548757, Fax:+33146547726, E-Mail: LASMEZAS@CEA.FR)

MAINTENANCE AND TRANSMISSION OF YEAST PRIONS: A MODEL SYSTEM, MICHAEL FRANCIS TUITE, UNIVERSITY OF KENT AT CANTERBURY (UK), (Tel: +441227823699, Fax: +441227763912, E-Mail: M.F.TUITE@UKC.AC.UK)

THE BOVINE PRION PROTEIN: FROM STRUCTURE ANALYSIS TO THE MOLECULAR MECHANISM OF CONFORMATIONAL TRANSITIONS, MARIA CATIA SORGATO, UNIVERSITA' DEGLI STUDI DI PADOVA, DIPARTIMENTO DI CHIMICA BIOLOGICA (IT), (Tel: +39498276136, Fax: +39498073310, E-Mail: SORGATO@CIV.BIO.UNIPD.IT)

STRUCTURE, FUNCTION AND INTERACTIONS OF PRION PROTEINS AND PRION PROTEIN DOMAINS, HANS A. KRETZSCHMAR, GEORG-AUGUST-UNIVERSITÄT (DE), (Tel: +49551392700, Fax:+49551398472, E-Mail: HKRETZ@MED.UNI-GOETTING)

TRAFFICKING PATHWAYS OF NORMAL AND PATHOLOGIC ISOFORMS OF THE PRION PROTEIN, SYLVAIN LEHMANN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR), (Tel:+33467613321, Fax: 33467521559, E-Mail: LSYLVAIN@VEGA.CRBM.CNRS)

CEREBELLAR NETWORKS ALTERATIONS IN PRION DISEASES, HERBERT AXELRAD, FACULTE DE MEDECINE PITIE – SALPETRIERE, UNIVERSITE PARIS VI (FR), (Tel: +33140779769, Fax: +33145829531, E-Mail: HAX@BIOMATH.JUSSIEU.FR)

ANALYSIS AND FUNCTION OF 14-3-3 ISOFORMS. EARLY DIAGNOSIS OF CREUTZFELD-JAKOB DISEASE, ALASTAIR AITKEN, MEDICAL RESEARCH COUNCIL (UK), (Tel: +441819593666, Fax:+441819064477, E-Mail: A-AITKEN@NIMR.MRC.AC.UK)

DIAGNOSIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES USING PrPSc/PrPc SPEC IFIC ANTIBODIES, HANS A. KRETZSCHMAR, GEORG-AUGUST-UNIVERSITÄT (DE), (Tel: +49551392700, Fax:+49551398472, E-Mail: HKRETZ@MED.UNI-GOETTING)

QUANTITATIVE ANALYSIS OF MR SCANS IN CREUTZFELDT-JAKOB DISEASE, ALAN COLCHESTER, UNIVERSITY OF KENT AT CANTERBURY, ELECTRONIC ENGINEERING LABORATORY (UK), (Tel: +441227827200, Fax: +441227827205, E-Mail: A.COLCHESTER@UKC.AC.UK)

DEVELOPMENT OF CELL CULTURE MODELS OF INFECTIOUS FORMS OF TSE, HUBERT LAUDE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, EPST (FR), (Tel:+33135642616, Fax: +33-134652621, E-Mail: LAUDE@BIOTEC.JOUY.INRA.FR)

RISK ASSESSMENT IN PRIMATES OF TSE TRANSMISSION TO HUMANS THROUGH FOOD AND BLOOD PRODUCTS, GERHARD HUNSMANN, DEUTSCHES PRIMATENZENTRUM GMBH (DE), (Tel: +495513851155, Fax:+495513851184, E-Mail: GHUNSMA@GWDG.DE)

TSE SPIKING EXPERIMENTS FOR PROCESS VALIDATIONS: EVALUATION OF DIFFERENT SOURCES OF INFECTIVITY AND SPIKING APPROACHES, HERWIG E. REICHL, HAEMOSAN ERZEUGUNG (AT), (Tel: +43316681713, Fax: +43316681713)

PRION DISEASES: MECHANISMS OF TRANSMISSION AND IDENTIFICATION OF TARGETS FOR POTENTIAL THERAPEUTICS, JOHN COLLINGE, THE IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (UK), (Tel: +441715943760, Fax: +441717067094, E-Mail: J.COLLINGE@IC.AC.UK)

DEVELOPMENT OF TSE THERAPIES BASED ON PRION PROTEIN-BINDING OLIGOSACCHARIDES, RUTH GABIZON, HADASSAH UNIVERSITY HOSPITAL, EIN KEREM (IS), (Tel: +97226777858, Fax:+97226437782, E-Mail: GABIZONR@HADASSAH.ORG.IT)

INACTIVATION OF THE CAUSATIVE AGENTS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES BY THERMOPHILIC AND HYPERTHERMOPHILIC PROTEASES, NEIL RAVEN, MICROBIAL RESEARCH AUTHORITY ACTING THROUGH ITS CENTRE FOR APPLIED MICROBIOLOGY AND RESEARCH (UK), (Tel: +441980612398, Fax: +441980611320, E-Mail: NEIL.RAVEN@CAMR.ORG.UK)

CONCERTED ACTION FOR THE SETTINGS UP OF MULTICENTRIC EPIDEMIOLOGICAL DATABASES AND BIOLOGICAL SAMPLES BANKS FOR SMALL RUMINANT SCRAPIE, FREDERIC LANTIER, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR), (Tel:+33247427868, Fax: +33247427779, E-Mail: LANTIER@TOURS.INRA.FR)

BUILDING A COMMON DATABASE ON SCIENTIFIC RESEARCH AND PUBLIC DECISION ON TSE IN EUROPE, PIERRE-BENOIT JOLY, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CENTRE DE AVIGNON E.P.S.T. (ETABLISSEMENT PUBLIC) (FR), (Tel: +33476825686, Fax: +33476825455, E-Mail: JOLY@GRENOBLE.INRA.FR)

MEASURES TO REDUCE CONTAMINATION OF MEAT AND ENVIRONMENT WITH CNS TISSUE DURING SLAUGHTER AND PROCESSING OF CATTLE AND SHEEP REMCORD, DR. DAVID HARBOUR, UNIVERSITY OF BRISTOL (UK), (Tel: +441179289208, Fax: +441179289505, E-Mail: DAVE.HARBOUR@BRIS.AC.UK)

GENERATION OF OVINE AND BOVINE PRP TRANSGENIC FOR THE DEVELOPMENT OF IMPROVED BIOASSAYS FOR BSE AND SCRAPIE AGENT DETECTION, DR. MARTIN GROSCHUP, FEDERAL RESEARCH CENTRE FOR VIRUS DISEASES OF ANIMALS, INSTITUTE FOR VACCINES AT THE FEDERAL RESEARCH (DE), (Tel: +497071967257, Fax:+497071967303, E-Mail: MARTIN.GROSCHUP@TUE.BFAY.DE)

IMPROVING PROSPECTS FOR SCRAPIE CONTROL IN SHEEP AND GOATS BY STUDY OF HOST GENOTYPES, TSE ISOLATES AND THEIR IN VIVO AND IN VITRO INTERACTION, DR JEAN-MICHEL ELSEN, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INRA-SAGA (FR), (Tel: +330561285174, Fax: +330561285353, E-Mail: ELSEN@TOULOUSE.INRA.FR)

NEW APPROACHES TO THE DIAGNOSIS; AND CONTROL OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES, DR MARK ROGERS, UNIVERSITY COLLEGE DUBLIN, DEPT. OF ZOOLOGY & BIOTECHNOLOGY CENTRE (IRL), (Tel: +35317062806, Fax: 35312692016, E-Mail: MARK.ROGERS@UCD.IE)

SEPARATION, IDENTIFICATION AND CHARACTERIZATION OF THE NORMAL AND ABNORMAL ISOFORM OF PRION PROTEIN FROM NORMAL AND EXPERIMENTALLY INFECTED FISH, PROF CARLA BOLIS, INSTITUTE OF PHARMACOLOGICAL SCIENCES UNIVERSITY OF MILAN, FACULTY OF PHARMACY (IT), (Tel: +390220488319, Fax: +390220488251, E-Mail: PIRACCIN@ISFUNIX.FARMA.UNIMI.IT)

ANALYSIS OF MOLECULAR FACTORS AFFECTING VARIABILITY IN BSE AND SCRAPIE SUSCEPTIBILITY, DR JOHN WILLIAMS, ROSLIN INSTITUTE (EDINBURGH), DIVISION OF MOLECULAR BIOLOGY (UK), (Tel: +441315274310, Fax: 441314400434, E-Mail: JOHN.WILLIAMS@BBSRC.AC.UK)

RELATIONSHIP BETWEEN CONFORMATION OF PRP, INFECTIVITY AND PATHOGENICITY OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) AS A BASIS FOR DIAGNOSIS, PROF DETLEV RIESNER, HEINRICH-HEINE-UNIVERSITAET DUESSELDORF, INSTITUT FUER PHYSIKALISCHE BIOLOGIE (DE), (Tel: +492118114840, Fax: +492118115167, E-Mail: RIESNER@BIOPHYS.UNI-DUESSELDORF.DE)

DEVELOPMENT OF A NOVEL DIAGNOSTIC TO ASSIST QUALITY ASSURANCE PROCEDURES IN EUROPEAN MEAT PRODUCTION, PROF. HEINZ C. SCHROEDER, JOHANNES GUTENBERG-UNIVERSITAET MAINZ, INSTITUT FUER PHYSIOLOGISCHE CHEMIE (DE), (Tel: +496131395791, Fax: +496131395243, E-Mail: HSCHROED@MZDMZA.ZDV.UNI-MAINZ.DE)

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PRESS RELEASES | PRESS RELEASES OF 1998 | 28.10.1998