Research & Innovation - Participant Portal

TOPIC : Personalised computer models and in-silico systems for well-being

Topic identifier: SC1-PM-17-2017
Publication date: 14 October 2015

Types of action: RIA Research and Innovation action
DeadlineModel:
Opening date:
single-stage
08 November 2016
Deadline: 14 March 2017 17:00:00

Time Zone : (Brussels time)
  Horizon 2020 H2020 website
Pillar: Societal Challenges
Work Programme Year: H2020-2016-2017
Topic Updates
  • 12 January 2017 14:15

    As of 1st January 2017, Switzerland is associated to the entire H2020 programme. In consequence, it is now also associated to this topic. In a nutshell this means that Swiss partners in a proposal are now on an equal footing with partners from EU Member States or other Associated Countries. For the details, please read this note.

Topic Description
Specific Challenge:

There is continuous progress in systems medicine, multi-scale modelling and patient-specific modelling, but these research opportunities have only been used sporadically in exploring well-being, disease prevention or rehabilitation. These areas of intervention are crucial for reducing healthcare demand, building sustainable healthcare systems and for assuring a healthy and motivated workforce. More, innovative methods are needed for better understanding the influence of biological (including microbiome), social, environmental, lifestyle, occupational, economic etc. factors on human physiology and thereby on well-being and health. This could help in identification of interventions for improving well-being and health: by increasing resilience to challenges and illness, by better prevention adapted to predispositions and behaviours (including gender), by better consideration given to functional troubles, by better strategies of recovery and rehabilitation after illness.

Scope:

Proposals should aim at the development of new integrative computer-models and simulation systems of acceptable validity, with the potential to being reused, built on open service platforms and with application in well-being, health and disease. The projects must include computer modelling and simulations able to aggregate various information sets e.g. molecular, biochemical, medical imaging, social, lifestyle, economic, occupational, microbiome, environmental, developmental, psychological, gender etc. to generate robust predictors for resilience to challenges and recovery from stresses and illness. The models will process and apply individual/patient-specific information in a multi-scale approach for integrating information from at least one biological level from molecule to entire body within a wider context. Proposals will focus on multi-disciplinary research in medicine, Social Sciences and Humanities (SSH) and ICT and should take advantage, when relevant, of existing large databases in clinical medicine, biomedical or occupational research, environmental sciences, SSH, so enabling and facilitating the accumulation and combining of complex and heterogeneous data collections. The models integrated in these multi-scale and multi-disciplinary approaches are to have their predictive capability validated by state-of-the-art clinical and/or laboratorial studies and/or against large health registries. Whenever relevant, proposals will integrate data collected over time in order to inform on individual trajectories with periods of well-being and periods of illness and on the heterogeneity of resilience and recovery that can be different during the individual lifetime.

The Commission considers that proposals requesting a contribution from the EU of between EUR 4 and 6 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Expected Impact:
  • Benefit for health and well-being: new personalised interventions for increasing resilience and recovery.
  • Advancements in medical computer-modelling and simulation that takes into account time scale.
  • Supporting predictive and preventive approaches in medicine, neurosciences and life sciences.
  • Improving knowledge about well-being and association with life circumstances.
Cross-cutting Priorities:

Gender
Socio-economic science and humanities

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.
 

  1. List of countries and applicable rules for funding: described in part A of the General Annexes of the General Work Programme.
    Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in some Horizon 2020 topics (to check funding conditions, follow the links to Australia, BrazilCanada, China, Hong Kong & Macau, IndiaJapan, Republic of Korea, Mexico, Russia, Taiwan, USA*).
    *Note that US participants in projects under the Horizon 2020 "Health, Demographic Change and Wellbeing" Societal Challenge are automatically eligible for EU-funding according to the provisions in the relevant work programme

     
  2. Eligibility and admissibility conditions: described in part B and C of the General Annexes of the General Work Programme.

    Proposal page limits and layout: Please refer to Part B of the standard proposal template.

     
  3. Evaluation

    3.1  Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme, with the following exceptions: The thresholds for each criterion in a single stage process will be 4, 4 and 3. The cumulative threshold will be 12.

    3.2 Submission and evaluation process: Guide to the submission and evaluation process

          
  4. Indicative timetable for evaluation and grant agreement:

    Information on the outcome of single-stage evaluation: maximum 5 months from the deadline for submission.
    Signature of grant agreements: maximum 8 months from the deadline for submission.

     
  5. Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:

    Research and Innovation Action:

    Specific provisions and funding rates
    Standard proposal template
    Specific evaluation form
    H2020 General MGA -Multi-Beneficiary
    Annotated Grant Agreement

    Essential information for clinical studies

     
  6. Additional provisions:

    Horizon 2020 budget flexibility

    Classified information

     
  7. Open access must be granted to all scientific publications resulting from Horizon 2020 actions.

    Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.

    Open access to research data
    The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in annex L of the Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.

    Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.

    Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.

    - Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs.

    - Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.

    The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.


     

  8. Additional documents:

    H2020 Work Programme 2016-17: Health, demographic change and wellbeing

    H2020 Work Programme 2016-17: Dissemination, Exploitation and Evaluation

    H2020 Work Programme 2016-17: General Annexes

    Legal basis: Horizon 2020 - Regulation of Establishment

    Legal basis: Horizon 2020 Rules for Participation

    Legal basis: Horizon 2020 Specific Programme

 

Additional documents

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