TOPIC : Pilot actions to build the foundations of a human cell atlas
|Publication date:||27 October 2017|
|Types of action:||RIA Research and Innovation action|
|DeadlineModel: Opening date:||single-stage 26 July 2018||Deadline:||16 April 2019 17:00:00|
|Time Zone : (Brussels time)|
Topic DescriptionSpecific Challenge:
For better understanding human health as well as improving the diagnosis, monitoring and treatment of diseases, greater knowledge is needed of the diverse cells found within the human body. Recent developments in single cell technologies, analytical methods and computational tools allow for unprecedented characterisation of human cells. A novel approach to address this challenge is the international Human Cell Atlas initiative (HCA) which will create molecular reference maps of all human cells . The potential scientific scope and organisation, including the community values to be adhered to by participating researchers, are described in a recent white paper.
European researchers are at the forefront of developments and thus, well-positioned to make an important contribution to building a human cell atlas. For this, it is imperative to bring together and strengthen European expertise to generate data and/or develop methods for in-depth, integrated molecular analysis and spatial resolution of single cells from complex biological systems such as human organs and tissues.Scope:
Each pilot action should demonstrate the utility of an interdisciplinary technological/biological platform to generate and integrate standardised molecular, cellular, biochemical and other data sets, characterising single cells or their nuclear components, their interactions and/or spatial location in tissues from one human organ. Platforms supporting analysis of tissues from more than one organ are also in scope. The primary focus should be on healthy tissues, though comparison between healthy and diseased tissues could be appropriate. Sex, age and ethnicity comparisons could also be considered. Proposals should provide detailed plans for quality management of tissue procurement and data in compliance with the relevant EU legislation (e.g. ethics, data protection).
Proposals supported under this topic must strictly adhere to the values, standards and practices of the HCA and provide for co-ordination with ongoing European and international activities. Plans for building sustainability beyond the funding period and scalability should be included. Proposals for pilot phase actions under this topic should be ready to deliver results for the HCA quickly, therefore project should have a duration of two years. To ensure coherence and communication between projects funded under this topic and with the HCA, the Commission will ensure an overall coordination mechanism between the projects. Proposals are expected to budget for the attendance of co-ordinators to regular meetings, where communication of results and exchange of knowledge gained from each pilot will be the objective
The Commission considers proposals requesting a contribution from the EU of between EUR 3 and 5 million would allow for the specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.Expected Impact:
- Timely contribution of project results to the HCA
- Effective and sustainable biological and/or technological platforms.
- Competitive and sustainable European role in HCA
- Strong involvement of European technology SMEs
- Laying the groundwork for improving diagnosis and treatment of disease
Topic conditions and documents
1. Eligible countries: described in Annex A of the Work Programme.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects. See the information in the Online Manual.
Proposal page limits and layout: please refer to Part B of the proposal template in the submission system below.
- Evaluation criteria, scoring and thresholds are described in Annex H of the Work Programme.
- Submission and evaluation processes are described in the Online Manual.
The thresholds for each criterion in a single stage process will be 4 (Excellence), 4 (Impact) and 3 (Implementation). The cumulative threshold will be 12.
4. Indicative time for evaluation and grant agreements:
Information on the outcome of evaluation (single-stage call): maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submission.
5. Proposal templates, evaluation forms and model grant agreements (MGA):
Research and Innovation Action:
6. Additional provisions:
To ensure coherence and communication between projects funded under this topic and with the HCA, the Commission will ensure an overall coordination mechanism between the projects. The respective options of Article 2, Article 31.6 and Article 41.4 2 of the Model Grant Agreement will be applied.
Members of consortium are required to conclude a consortium agreement, in principle prior to the signature of the grant agreement.
7. Open access must be granted to all scientific publications resulting from Horizon 2020 actions.
Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
Open access to research data
The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in Annex L of the Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.
Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.
Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.
Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs. See the Online Manual.
Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.
The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.
8. Additional documents:
LEARs, Account Administrators or self-registrants can publish partner requests for open and forthcoming topics after logging into the Participant Portal.
To access the Electronic Sumission Service, please click on the submission-button next to the type of action that corresponds to your proposal. You will then be asked to confirm your choice of the type of action and topic, as these cannot be changed in the submission system. Upon confirmation, you will be linked to the correct entry point.
To access existing draft proposals for this topic, please login to the Participant Portal and select the My Proposals page of the My Area section.
|Type of Action||Research and Innovation action [RIA]|
|Topic||Pilot actions to build the foundations of a human cell atlas - SC1-BHC-31-2019|
|Guidance on proposal submission:||H2020 online manual|
H2020 Online Manual is your guide on the procedures from proposal submission to managing your grant.
Participant Portal FAQ – Submission of proposals.
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