Research & Innovation - Participant Portal

Search

TOPIC : Nanotechnologies for imaging cellular transplants and regenerative processes in vivo

Topic identifier: NMBP-15-2017
Publication date: 14 October 2015

Types of action: RIA Research and Innovation action
DeadlineModel:
Opening date:
two-stage
11 May 2016
Deadline:
2nd stage Deadline:
27 October 2016 17:00:00
04 May 2017 17:00:00

Time Zone : (Brussels time)
  Horizon 2020 H2020 website
Pillar: Industrial Leadership
Work Programme Year: H2020-2016-2017
Topic Updates
  • 11 January 2017 10:28

    Switzerland as associated country

    From 1 January 2017 Switzerland is associated to the whole Horizon 2020 programme instead of the previous partial association.

    This applies to all the grant agreements signed on 1 January 2017 and afterwards.

    For more information please see the relevant Note on the Participant Portal.

Topic Description
Specific Challenge:

Detection and monitoring of cell and tissue transplants in vivo is of utmost importance for development of clinical cell therapy. Suitable nanotechnology-based imaging approaches with high sensitivity should allow for monitoring of cell viability, engraftment and distribution, also through the use of nanomaterials for cells marking. Appropriate imaging techniques have been developed for application in small animals, but are not available yet for use in preclinical large animal models and patients. In particular, such technologies will represent an important safety measure enabling early detection of cell based therapy.

Scope:

Proposals should focus on the following:

  • Development of highly sensitive imaging approaches enabling discrimination of living cell and tissue transplants based e.g. on optical imaging, magnetic resonance imaging and / or nuclear medicine techniques;
  • Monitoring should be highly sensitive, in best case allowing for detection of single cells and cell morphologies;
  • Possibility of non-invasive whole body monitoring (magnetic, optical) in large animals;
  • Development of clinically applicable imaging approaches, taking into account medical regulatory aspects;
  • Interpretation of the data with theoretical models (to be developed if necessary).

As relevant, the proposed activities should address sex and gender specific aspects[1].

Activities are expected to commence at Technology Readiness Levels 3/4 and reach 5/6.

The Commission considers that proposals requesting a contribution from the EU between EUR 5 and 7 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.

Expected Impact:
  • Availability of novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of cellular transplants in preclinical large animal models and patients;
  • Imaging technologies facilitating the provision of new regenerative therapies to patients;
  • Opening of a new market sector for imaging equipment and supplies, reinforcement of the European healthcare supply chain and improvement of the competitiveness of the European healthcare sector.

Proposals should include a business case and exploitation strategy, as outlined in the Introduction to the LEIT part of this Work Programme.

Cross-cutting Priorities:

Gender

[1]See definition of the 'gender dimension approach' in the introduction of this Work Programme part.

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.
 

  1. LIST OF COUNTRIES and APPLICABLE RULES FOR FUNDING
    described in part A of the General Annexes of the General Work Programme.

    Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects (follow the links to Australia, Brazil, Canada, China, Hong Kong &Macau, India, Japan, Republic of Korea, Mexico, Russia, Taiwan).
     
  2. ELIGIBILITY and ADMISSIBILITY CONDITIONS
    described in part B and C of the General Annexes of the General Work Programme.

    Proposal page limits and layout: Please refer to Part B of the standard proposal template.


     
  3. EVALUATION

    3.1  Evaluation criteria and procedure, scoring and threshold:
    The criteria, scoring and threshold are described in General Annex H of the work programme.
    The following exceptions apply:

    For single-stage and second-stage evaluations, the threshold for the criteria Excellence and Impact will be 4. The overall threshold, applying to the sum of the three individual scores, will be 12.

    The procedure for setting a priority order for proposals with the same score is given in General Annex H of the work programme. The following exceptions apply:

    Under 3 (a)
    Proposals are first ranked in separate lists according to the topics against which they were submitted (‘topic ranked lists’). When comparing ex aequo proposals from different topics, proposals having a higher position in their respective 'topic ranked list' will be considered to have a higher priority in the overall ranked list.

    Under 3 (b)
    For all topics and types of action, the prioritisation will be done first on the basis of the score for Impact, and then on that for Excellence.

    3.2 Submission and evaluation process: Guide to the submission and evaluation process
        

  4. INDICATIVE TIMETABLE for EVALUATION and GRANT AGREEMENT

    Information on the outcome of two-stage evaluation:
          For stage 1: maximum 3 months from the deadline for submission.
          For stage 2: maximum 5 months from the deadline for submission.
    Signature of grant agreements: maximum 8 months from the deadline for submission.

     
  5. PROVISIONS, PROPOSAL TEMPLATES and EVALUATION FORMS
    for the type of action under this topic


    Research and Innovation Action:

    Specific provisions and funding rates
    Standard proposal template
    Standard evaluation form
    H2020 General MGA -Multi-Beneficiary
    Annotated Grant Agreement
     
  6. ADDITIONAL PROVISIONS

    Horizon 2020 budget flexibility

    Classified information

    Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.

    Financial support to Third Parties – where a topic description foresees financial support to Third Parties, these provisions apply.

     
  7. OPEN ACCESS

    Open access must be granted to all scientific publications resulting from Horizon 2020 actions.

    Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.

    Open access to research data
    The Open Research Data Pilot has been extended to cover all Horizon 2020 topics for which the submission is opened on 26 July 2016 or later. Projects funded under this topic will therefore by default provide open access to the research data they generate, except if they decide to opt-out under the conditions described in annex L of the Work Programme. Projects can opt-out at any stage, that is both before and after the grant signature.

    Note that the evaluation phase proposals will not be evaluated more favourably because they plan to open or share their data, and will not be penalised for opting out.

    Open research data sharing applies to the data needed to validate the results presented in scientific publications. Additionally, projects can choose to make other data available open access and need to describe their approach in a Data Management Plan.

    - Projects need to create a Data Management Plan (DMP), except if they opt-out of making their research data open access. A first version of the DMP must be provided as an early deliverable within six months of the project and should be updated during the project as appropriate. The Commission already provides guidance documents, including a template for DMPs.

    - Eligibility of costs: costs related to data management and data sharing are eligible for reimbursement during the project duration.

    The legal requirements for projects participating in this pilot are in the article 29.3 of the Model Grant Agreement.

     

  8. ADDITIONAL DOCUMENTS

    Legal basis: Horizon 2020 - Regulation of Establishment

    Legal basis: Horizon 2020 Rules for Participation

    Legal basis: Horizon 2020 Specific Programme

    H2020 Work Programme 2016-17: Introduction

    H2020 Work Programme 2016-17: Introduction to Leadership in enabling and industrial technologies (LEITs)

    H2020 Work Programme 2016-17: Nanotechnologies, advanced materials, advanced manufacturing and processing, biotechnology

    H2020 Work Programme 2016-17: Cross-cutting activities (Focus Areas)

    H2020 Work Programme 2016-17: Dissemination, Exploitation and Evaluation


    H2020 Work Programme 2016-17: General Annexes

 

Submission Service

No submission system is open for this topic.

Get support

ASSISTANCE

National Contact Points (NCP) - contact your NCP for further assistance.

Enterprise Europe Network – contact your EEN national contact for advice to businesses with special focus on SMEs. The support includes guidance on the EU research funding.

Partner Search Services help you find a partner organisation for your proposal.

 

HELPDESK

Research Enquiry Service – ask questions about any aspect of European research in general and the EU Research Framework Programmes in particular.

H2020 Online Manual your online guide on the procedures from proposal submission to managing your grant.

Participant Portal FAQ – Submission of proposals.

IT Helpdesk- contact the Participant Portal IT helpdesk for questions such as forgotten passwords, access rights and roles, technical aspects of submission of proposals, etc.

European IPR Helpdesk assists you on intellectual property issues

 

 

MORE

Ethics – for compliance with ethical issues, see the Participant Portal and Science and Society Portal

CEN and CENELEC, the European Standards Organisations, advise you how to tackle standardisation in your project proposal. Contact CEN-CENELEC Research Helpdesk at research@cencenelec.eu.

The European Charter for Researchers and the Code of Conduct for their recruitment