Research & Innovation - Participant Portal

TOPIC : Development of Quantitative System Toxicology (QST) approaches to improve the understanding of the safety of new medicines

Topic identifier: IMI2-2015-06-01
Publication date: 06 October 2015

Types of action: RIA Research and Innovation action
Opening date:
06 October 2015
2nd stage Deadline:
12 January 2016 17:00:00
14 June 2016 17:00:00

Time Zone : (Brussels time)
  Horizon 2020
Topic Description
Specific Challenge:

Modeling is fundamental to drug development. But there is the need to develop innovative methodologies and practices to integrate the ‘omics analysis and network analysis with quantitative mechanism-based models to form a new approach to drug safety assessment. The emerging field of Quantitative Systems Pharmacology (QSP) seeks to address this methodological gap via the development of mathematical models that account for the mechanisms underlying the response of integrated biological systems at the level of target cells and organs.


The scope of this proposal is to 1) develop Quantitative Systems Toxicology (QST) models for drug-induced toxicity with the focus on four different organ systems: Heart, Liver, Kidney and the Gastrointestinal (GI)-immune system, and 2) use this QST approach for the prediction of clinical toxicity using preclinical data.

Expected Impact:

The results of this action will help to address the needs of the toxicology community for more comprehensive coverage of mechanistic toxicity pathways from which to define a mechanism-based screening approach.

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.
The budget breakdown for this call is given at the end of the Call topics text, in the Call Conditions section, as well as the following information :

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  5. Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:

    IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):

    Summary of the most relevant provisions for participating in IMI2 actions
    Standard proposal template
    Standard evaluation form
    IMI2 Model Grant Agreement
    Template for essential clinial trial information

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No submission system is open for this topic.

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