TOPIC : Nanotechnologies for imaging cellular transplants and regenerative processes in vivo
|Publication date:||14 October 2015|
|Types of action:||RIA Research and Innovation action|
|DeadlineModel: Planned opening date:||two-stage 11 May 2016||Deadline: 2nd stage Deadline:||
27 October 2016 17:00:00
04 May 2017 17:00:00
|Time Zone : (Brussels time)|
Topic DescriptionSpecific Challenge:
Detection and monitoring of cell and tissue transplants in vivo is of utmost importance for development of clinical cell therapy. Suitable nanotechnology-based imaging approaches with high sensitivity should allow for monitoring of cell viability, engraftment and distribution, also through the use of nanomaterials for cells marking. Appropriate imaging techniques have been developed for application in small animals, but are not available yet for use in preclinical large animal models and patients. In particular, such technologies will represent an important safety measure enabling early detection of cell based therapy.Scope:
Proposals should focus on the following:
- Development of highly sensitive imaging approaches enabling discrimination of living cell and tissue transplants based e.g. on optical imaging, magnetic resonance imaging and / or nuclear medicine techniques;
- Monitoring should be highly sensitive, in best case allowing for detection of single cells and cell morphologies;
- Possibility of non-invasive whole body monitoring (magnetic, optical) in large animals;
- Development of clinically applicable imaging approaches, taking into account medical regulatory aspects;
- Interpretation of the data with theoretical models (to be developed if necessary).
As relevant, the proposed activities should address sex and gender specific aspects.
Activities are expected to commence at Technology Readiness Levels 3/4 and reach 5/6.
The Commission considers that proposals requesting a contribution from the EU between EUR 5 and 7 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts.Expected Impact:
- Availability of novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of cellular transplants in preclinical large animal models and patients;
- Imaging technologies facilitating the provision of new regenerative therapies to patients;
- Opening of a new market sector for imaging equipment and supplies, reinforcement of the European healthcare supply chain and improvement of the competitiveness of the European healthcare sector.
Proposals should include a business case and exploitation strategy, as outlined in the Introduction to the LEIT part of this Work Programme.
See definition of the 'gender dimension approach' in the introduction of this Work Programme part.
Topic conditions and documents
Please read carefully all provisions below before the preparation of your application.
- LIST OF COUNTRIES and APPLICABLE RULES FOR FUNDING
described in part A of the General Annexes of the General Work Programme.
Note also that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon 2020 projects (follow the links to Australia, Brazil, Canada, China, Hong Kong &Macau, India, Japan, Republic of Korea, Mexico, Russia, Taiwan).
- ELIGIBILITY and ADMISSIBILITY CONDITIONS
described in part B and C of the General Annexes of the General Work Programme.
Proposal page limits and layout: Please refer to Part B of the standard proposal template.
3.1 Evaluation criteria and procedure, scoring and threshold: described in part H of the General Annexes of the General Work Programme , with the following exceptions:
For single-stage and second-stage evaluations, the threshold for the criteria Excellence and Impact will be 4.
The overall threshold, applying to the sum of the three individual scores, will be 12.
In case of equal overall scores in the ranked list, the priority order of proposals will be established in accordance with part H of the General Annexes, except that proposals will be ranked on the basis of individual scores for the Impact criterion before the Excellence criterion.
In case of equal overall scores in the ranked list, the priority order of proposals will be established in accordance with part H of the General Annexes, except, when comparing ex aequo proposals of different topics, the proposals will be ranked first according to the position in the topic ranked lists
3.2 Submission and evaluation process: Guide to the submission and evaluation process
- INDICATIVE TIMETABLE for EVALUATION and GRANT AGREEMENT
Information on the outcome of two-stage evaluation:
For stage 1: maximum 3 months from the deadline for submission.
For stage 2: maximum 5 months from the deadline for submission.
Signature of grant agreements: maximum 8 months from the deadline for submission.
- PROVISIONS, PROPOSAL TEMPLATES and EVALUATION FORMS
for the type of action under this topic
Research and Innovation Action:
Specific provisions and funding rates
Standard proposal template
Standard evaluation form
H2020 General MGA -Multi-Beneficiary
Annotated Grant Agreement
- ADDITIONAL PROVISIONS
Horizon 2020 budget flexibility
Technology readiness levels (TRL) – where a topic description refers to TRL, these definitions apply.
Financial support to Third Parties – where a topic description foresees financial support to Third Parties, these provisions apply.
- OPEN ACCESS
must be granted to all scientific publications resulting from Horizon 2020 actions, and proposals must refer to measures envisaged.
Where relevant, proposals should also provide information on how the participants will manage the research data generated and/or collected during the project, such as details on what types of data the project will generate, whether and how this data will be exploited or made accessible for verification and re-use, and how it will be curated and preserved.
- ADDITIONAL DOCUMENTS
Legal basis: Horizon 2020 - Regulation of Establishment
Legal basis: Horizon 2020 Rules for Participation
Legal basis: Horizon 2020 Specific Programme
H2020 Work Programme 2016-17: Introduction
H2020 Work Programme 2016-17: Introduction to Leadership in enabling and industrial technologies (LEITs)
H2020 Work Programme 2016-17: Nanotechnologies, advanced materials, advanced manufacturing and processing, biotechnology
H2020 Work Programme 2016-17: Cross-cutting activities (Focus Areas)
H2020 Work Programme 2016-17: Dissemination, Exploitation and Evaluation
H2020 Work Programme 2016-17: General Annexes
The H2020 Work Programme 2016-17 is currently under revision.
An updated version is expected to be published by late July 2016.
The submission service will be opened as soon as the updated version of the H2020 Work Programme 2016-17 is published.
Please consult the updated version of the Work Programme when preparing your proposal.
National Contact Points (NCP) - contact your NCP for further assistance.
Enterprise Europe Network – contact your EEN national contact for advice to businesses with special focus on SMEs. The support includes guidance on the EU research funding.
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H2020 Online Manual your online guide on the procedures from proposal submission to managing your grant.
Participant Portal FAQ – Submission of proposals.
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