Research & Innovation - Participant Portal

TOPIC : PATHOLOGICAL NEURON-GLIA INTERACTIONS IN NEUROPATHIC PAIN

Topic identifier: IMI2-2015-07-03
Publication date: 18 December 2015

Types of action: IMI2-RIA Research and Innovation action
DeadlineModel:
Opening date:
two-stage
18 December 2015
Deadline:
2nd stage Deadline:
17 March 2016 17:00:00
06 September 2016 17:00:00

Time Zone : (Brussels time)
  Horizon 2020
Topic Description
Specific Challenge:

Neuropathic pain (NP) is a widespread disease affecting 6-8% of the population, causing great misery, and incurring huge costs to society. Current therapies are inadequate, addressing only the symptoms not the causes of the pain. In fact, the aetiologies of the disease are poorly understood, hindering the development of new analgesics with improved efficacies.

This topic proposes to study the interactions between hiPS cell derived neurons and glia to guide the discovery of effective analgesics and of clinically useful biomarkers, and help improve the health care of millions of patients.

For more information, please see the IMI2 Call 7 topic text.

Scope:

The Neuropathic Pain project will:

  • Develop in vitro cell cultures which reflect the interactions between neurons and glia in healthy neuronal tissues
  • Use HCS technology to perform fast multiparametric screening of many conditions.
  • Analyse the intra- and intercellular signalling pathways in samples of rat tissue
  • Collect enough information to permit the definition of interventions which at least alleviate NP better than current treatments

For more information, please see the IMI2 Call 7 topic text.

Expected Impact:

Deepen the understanding of clinical NP at the cellular and genetic levels.

In vitro assays will be developed to improve methods for investigating

Greatly improve the chances of identifying and developing curative analgesic therapies for chronic NP which would enhance the quality of life for millions of patients, and bring substantial cost savings in healthcare.

For more information, please see the IMI2 Call 7 topic text.

Topic conditions and documents

Please read carefully all provisions below before the preparation of your application.

You can access the description of the different topics in the Call topics text.

The budget breakdown for this Call is given at the end of the Call topics text, in the Call Conditions section (page 78), as well as the following information : 
 

  1. List of countries and applicable rules for funding
     
  2. Eligibility and admissibility conditions
     
  3. Evaluation criteria and procedure, scoring and threshold : described in the IMI Manual for Submission, Evaluation and Grant award
     
  4. Indicative timetable for evaluation and grant agreement
     
  5. Provisions, proposal templates and evaluation forms for the type(s) of action(s) under this topic:

    IMI2 Research and Innovation Action (IMI2-RIA) and (IMI2-IA):

    Summary of the most relevant provisions for participating in IMI2 actions
    Standard proposal template
    Standard evaluation form
    IMI2 Model Grant Agreement
    Template for Essential Clinical Trials Information

    MI2 Coordination and Support Action (IMI2-CSA):

    Summary of the most relevant provisions for participating in IMI2 actions
    Standard proposal template
    Standard evaluation form
    IMI2 Model Grant Agreement
    Template for Essential Clinical Trials Information
     

 

Submission Service

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