Scientists from the University of Southampton in the UK have identified the molecular system that could help develop treatments for Alzheimer's disease. This research, funded by a Marie Curie fellowship from the European Union and a pilot research grant from Alzheimer's Research UK, reveals the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.
An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's or prion disease, is the generation of an innate inflammatory reaction within the brain. Results from the study open new avenues for the regulation of this reaction and provide new insights into the biology of the microglial cells behind it.
Lead author of the paper (published in The Journal of Neuroscience) Dr Diego Gomez-Nicola holds his Marie Curie Intra-European Fellowship within the CNS Inflammation group at the University of Southampton. He says: "The understanding of microglial biology during neurodegenerative diseases is crucial for the development of potential therapeutic approaches to control the harmful inflammatory reaction. These potential interventions could modify or arrest neurodegenerative diseases like Alzheimer's disease. The future potential outcomes of this line of research would be rapidly translated into the clinics of neuropathology, and would improve the quality of life of patients with these diseases."
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