Navigation path

Themes
Agriculture & food
Energy
Environment
ERA-NET
Health & life sciences
Human resources & mobility
Industrial research
Information society
Innovation
International cooperation
Nanotechnology
Pure sciences
Research infrastructures
Research policy
Science & business
Science in society
Security
SMEs
Social sciences and humanities
Space
Special Collections
Transport

Countries
Countries
  Argentina
  Australia
  Austria
  Belgium
  Benin
  Brazil
  Bulgaria
  Canada
  Chile
  China
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Egypt
  Estonia
  Finland
  France
  Georgia
  Germany
  Ghana
  Greece
  Hungary
  Iceland
  India
  Ireland
  Israel
  Italy
  Japan
  Kazakhstan
  Kenya
  Korea
  Latvia
  Lithuania
  Luxembourg
  Malta
  Mexico
  Montenegro
  Morocco
  Namibia
  Netherlands
  Nigeria
  Norway
  Peru
  Poland
  Portugal
  Romania
  Russia
  Serbia
  Slovakia
  Slovenia
  South Africa
  Spain
  Swaziland
  Sweden
  Switzerland
  Taiwan
  Tanzania
  Tunisia
  Turkey
  Ukraine
  United Kingdom
  United States


   Success Stories

Last Update: 19-12-2012  
Related category(ies):
Health & life sciences

 

Countries involved in the project described in the article:
Netherlands  |  Switzerland
Add to PDF "basket"

CelluCart – Industry-academia partnership for novel treatment of knee injuries

A Marie Curie Action (MCA) played a pivotal role in progressing the careers of two young medical researchers, bringing new hope of speedy recovery to millions of future sufferers of knee cartilage damage, and enabling a medical start-up company based in the Netherlands to develop a ground-breaking cartilage-repair technology and speed up its progress towards clinical trials and the eventual prospect of commercialisation.


© Fotolia, 2012

At the heart of the project, entitled CelluCart, was the concept of 'Cellular Cartilage Instruction', a technique discovered by a development-stage orthopaedic company in the Netherlands called CellCoTec. The technique is based on the observed capability of healthy cartilage cells, taken from the patient's own body, to interact with stem cells taken from the patient's bone marrow, to 'instruct' the formation of new cartilage tissue.

In the words of the CelluCart project co-ordinator, Dr Jens Riesle, who is also CellCoTec's Chief Scientific Officer and Executive Director, the Marie Curie Fellowship, designed to attract and support the mobility of talented young researchers, was 'a very helpful step' in the successful development of the Cellular Cartilage Instruction process.

Granted under the Transfer of Knowledge scheme, with the specific aim of fostering strategic partnerships between industry and academia, the €164,000 Marie Curie Fellowship was the key to an important piece of collaboration between CellCoTec and the Department of Surgery at University Hospital Basel in Switzerland.

The Marie Curie Action enabled CellCoTec to employ a scientist who spent a year on secondment at University Hospital Basel, acquiring knowledge of effective cell sources, while a researcher from Basel was able to spend a period working within CellCoTec and subsequently transfer knowledge about Cellular Cartilage Instruction back to University Hospital Basel.

The two Marie Curie-funded scientists played lead roles in the central piece of research which allowed the technique of Cellular Cartilage Instruction to move ahead. The key issue to resolve had been the need to establish which particular types of cartilage cells (articular or nasal) and which particular types of stem cells (bone marrow or adipose tissue) were the optimal combination to achieve new cartilage tissue generation. The work of the two researchers, with others, provided the verification that articular cartilage cells and bone marrow stem cells provided the most effective combination.

The results of the research were published in a paper in the Journal of Cellular Physiology in February 2011, entitled Enhanced Chondrocyte Proliferation and Mesenchymal Stromal Cells Chondrogenesis in Coculture Pellets Mediate Improved Cartilage Formation, with the two researchers, Chitrangada Acharya and Adetola Adesida, named as lead authors.

The Cellular Cartilage Instruction technique has been granted a series of patents in Europe, the USA and Australia and is now undergoing a 30-patient clinical trial following a successful 10-patient pilot clinical trial which was completed in 2011.

Following on from the success of the CelluCart project, Adetola Adesida has been appointed Assistant Professor of Surgery at the University of Alberta, Canada, and Chitrangada Acharya is now a Post Doctoral fellow at the University of California, Davis, Medical Center at Sacramento.

At CellCoTec, Dr Riesle looks back on the outcomes of CelluCart, not only in terms of the practical benefits it brought to his company, but also in terms of the scientific outcome, the knowledge exchange, and – not least - the ultimate benefits to knee cartilage patients. 'It really was a win-win situation,' he concludes.

Project details

  • Participants:Netherlands(coordinator), Switzerland
  • FP6 Project N° 42418
  • EU contribution: € 164 000
  • Duration: September 2007 to August 2009

Convert article(s) to PDF

No article selected


loading


Search articles

Notes:
To restrict search results to articles in the Information Centre, i.e. this site, use this search box rather than the one at the top of the page.

After searching, you can expand the results to include the whole Research and Innovation web site, or another section of it, or all Europa, afterwards without searching again.

Please note that new content may take a few days to be indexed by the search engine and therefore to appear in the results.

Print Version
Share this article
See also

Project web site

Project information on CORDIS

Contacts
Unit A1 - External & internal communication,
Directorate-General for Research & Innovation,
European Commission
Tel : +32 2 298 45 40
  Top   Research Information Center