Drug therapy tailored to your genes

Your response to a drug depends, in part, on your genetic make-up. An EU-funded project is developing a system to help doctors take into account a patient's genotype when prescribing treatment, for safer and more effective therapy.

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Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Bosnia and Herzegovina
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czechia
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  French Polynesia
  Georgia


  Infocentre

Published: 19 March 2019  
Related theme(s) and subtheme(s)
Health & life sciencesGenomics
Research policyHorizon 2020
Countries involved in the project described in the article
Austria  |  France  |  Germany  |  Greece  |  Italy  |  Slovenia  |  Spain  |  Sweden  |  United Kingdom
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Drug therapy tailored to your genes

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© Sergey Nivens #111170535, 2019 source: stock.adobe.com

The science of pharmacogenomics (PGx) studies how genetic variability affects an individual’s response to a drug. Most patients metabolise a medication as expected. But some eliminate it from the body before it can do its work, while others process it slowly, causing it to build up in the body and risk an overdose.

Researchers in the U-PGx project are investigating how PGx could help doctors and pharmacists better treat patients. Advance knowledge of how an individual is likely to process a given drug could ensure that doctors can choose safe, effective therapy without trial and error.

The project has developed an electronic support system for choosing treatment based on a patient’s pharmacogenomic profile. Prescribers would match medication and dose to the patient’s genotype, with a warning given if a drug is ordered for a patient at risk of a dangerous reaction.

The first steps towards testing this system in real life were taken in U-PGx’s clinical study PREPARE (Preemptive Pharmacogenomic Testing for Preventing Adverse Drug Reactions). Around 8 000 patients are being tested for genetic markers that could indicate how they react to more than 40 commonly prescribed drugs. Half the group are prescribed the drug they need using their genetic data, with the other half prescribed drugs using a standard-of-care approach, i.e. without taking genetic data into account.

Results will show whether pharmacogenomic testing impacts therapy outcomes and is feasible and cost-effective on a large scale. Seven clinical centres from across Europe are taking part, helping to ensure that results are representative of Europe as a whole.

U-PGx researchers will also use the study’s results to draw up proposals for an EU-wide strategy on the clinical use of PGx. In parallel, the researchers are raising awareness of its potential among patients, health-care professionals, regulators and other stakeholders.

Project details

  • Project acronym: U-PGx
  • Participants: Netherlands (Coordinator), UK, Germany, Sweden, Austria, France, Italy, Spain, Greece, Slovenia
  • Project N°: 668353
  • Total costs: € 14 936 613
  • EU contribution: € 14 936 613
  • Duration: January 2016 to December 2020

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