Navigation path

Themes
Agriculture & food
Energy
Environment
ERA-NET
Health & life sciences
Human resources & mobility
Industrial research
  Building & construction
  Coal & steel
  Industrial processes & robotics
  Materials & products
  Nanotechnology
  Standards, measures & testing
  Other
Information society
Innovation
International cooperation
Nanotechnology
Pure sciences
Research infrastructures
Research policy
Science & business
Science in society
Security
SMEs
Social sciences and humanities
Space
Special Collections
Transport

Countries
Countries
  Argentina
  Australia
  Austria
  Belarus
  Belgium
  Benin
  Botswana
  Brazil
  Bulgaria
  Cameroon
  Canada
  Chile
  China
  Colombia
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Egypt
  Estonia
  Finland
  France
  Georgia
  Germany
  Ghana
  Greece
  Hungary
  Iceland
  India
  Ireland
  Israel
  Italy
  Japan
  Kazakhstan
  Kenya
  Korea
  Latvia
  Lichtenstein
  Lithuania
  Luxembourg
  Madagascar
  Malta
  Mexico
  Montenegro
  Morocco
  Namibia
  Netherlands
  Nigeria
  Norway
  Peru
  Poland
  Portugal
  Romania
  Russia
  Senegal
  Serbia
  Slovakia
  Slovenia
  South Africa
  Spain
  Swaziland
  Sweden
  Switzerland
  Taiwan
  Tanzania
  Tunisia
  Turkey
  Uganda
  Ukraine
  United Kingdom
  United States


This page was published on 18/06/2007
Published: 18/06/2007

   Industrial research

Last Update: 18-06-2007  
Related category(ies):
Health & life sciences  |  Industrial research

 

Add to PDF "basket"

European scientists produce guidelines for acetylsalicylic acid hypersensitivity

Do you have a headache? Then you might want to reach for pain medication that contains acetylsalicylic acid (ASA), the drug commonly known as aspirin, in order to gain some relief. However, although it is such a common form of medication, few realise that in some individuals it can cause a serious reaction. For this reason, European scientists have called for a more systematic diagnosis of ASA hypersensitivity, publishing new guidelines on how to diagnose the condition.

ASA is so common side effects are often overlooked.  © Matt+
ASA is so common that side effects are often overlooked.
A position paper by a team of European scientists from the Global Allergy and Asthma European Network (GA²LEN) has recently been published on the Allergy Journal website. The guidelines were drawn up for health professionals and propose detailed protocols for challenge tests. The tests may be by the oral, bronchial or nasal route. The paper is approved by the European Academy of Allergology and Clinical Immunology (EAACI) and GA²LEN partners.

Prof. Szczeklik, the main author of the paper, states ‘This position paper will enable physicians to proceed with diagnosis.’ A large number of non-steroidal, anti-inflammatory drugs for common complaints, such as headaches, are unsuitable for patients suffering from hypersensitivity. ‘A proper diagnosis will have a real benefit for them as they will be directed by their doctors to alternative medication that are completely safe to take, without any side-effects.’

The majority of people can tolerate ASA without any problems. For some, however, ASA and other non-steroidal anti-inflammatory (NSAIDS) drugs can trigger allergy-like asthma, sinusitis or urticaria. The reaction by a sufferer can be as violent and life-threatening as an asthma attack and anaphylaxis. Therefore, establishing a diagnosis of ASA hypersensitivity is of the utmost importance.

Hypersensitivity to ASA has been known since the early 20th century and nowadays it is considered to be one of the most common adverse reactions to a medicinal product. There is a problem, however, in that it remains largely under-diagnosed.

The only way to identify ASA sensitivity is by taking a challenge test. This involves the patient being administered small doses of ASA. These are regularly increased, under the direct supervision of a doctor experienced in carrying out such procedures, and within a clinical environment. Furthermore, emergency resuscitation equipment should be on hand and the patient should be in a stable condition.

The patient may be considered to be hypersensitive if their lung function is depressed by more than 20%. Symptoms of ASA hypersensitivity include tightness of the chest and wheezing and nasal congestion. Other reactions include redness of the skin of the upper thorax and face, nausea, stomach cramps, etc. It has been estimated that at least 0.5% of the general population is known to suffer from ASA sensitivity; however, this figure rises for asthmatics, who are especially likely to be affected. According to a recent study, about 20% of asthmatic adults are hypersensitive to ASA.

Convert article(s) to PDF

No article selected


loading


Search articles

Notes:
To restrict search results to articles in the Information Centre, i.e. this site, use this search box rather than the one at the top of the page.

After searching, you can expand the results to include the whole Research and Innovation web site, or another section of it, or all Europa, afterwards without searching again.

Please note that new content may take a few days to be indexed by the search engine and therefore to appear in the results.

Print Version
Share this article
See also

Allergy Journal
Global Allergy and Asthma European Network





  Top   Research Information Center