EU-Africa... Time to unwrap compatible biobanking!

As more and more people travel and global warming paves the way for diseases to spread, human health and welfare are no longer the preserve of single countries, regions or even continents. European researchers teamed up with African partners to bridge the gap in biomedical research and biobanking practices between the regions. Its biobank-in-a-box is now ready to be unwrapped.

Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  French Polynesia
  Georgia

Countries
Countries
  Algeria
  Argentina
  Australia
  Austria
  Bangladesh
  Belarus
  Belgium
  Benin
  Bolivia
  Brazil
  Bulgaria
  Burkina Faso
  Cambodia
  Cameroon
  Canada
  Cape Verde
  Chile
  China
  Colombia
  Costa Rica
  Croatia
  Cyprus
  Czech Republic
  Denmark
  Ecuador
  Egypt
  Estonia
  Ethiopia
  Faroe Islands
  Finland
  France
  French Polynesia
  Georgia


 

Published: 22 August 2018  
Related theme(s) and subtheme(s)
Health & life sciencesCommunicable diseases  |  Health systems & management  |  Medical research
Research policyHorizon 2020
Countries involved in the project described in the article
Austria  |  France  |  Kenya  |  Nigeria  |  Sweden  |  Uganda  |  Zambia
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EU-Africa... Time to unwrap compatible biobanking!

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© rh2010 #200277997, 2018 fotolia.com

The resurgence of diseases like Ebola points to the need for coordinated global responses to health threats, which means doing things like biological research in standardised ways. But there is a problem: regions store and manage biological samples (biobanks) differently.

Tissue samples, genetic information and other vital sources of biological data used to understand human health need to be managed the same, regardless of the source country. IT systems used to process the samples and analyse the data – known as bioinformatics – need to be interoperable. Researchers working in the field or lab need to follow the same practices to ensure the findings are reliable.

“We desperately needed a globally standardised approach to make sure that no matter where a disease or health crisis breaks out, research can quickly respond, knowing that everyone is on the same page,” says Erik Bongcam-Rudloff, a professor and head of bioinformatics infrastructure at the Swedish University of Agricultural Sciences. “Thanks to EU support for our B3Africa project, and working with our research partners, we’ve created a platform with technical and intellectual resources to bridge European and African biobanking and biological research.”

B3Africa’s seven-country international consortium, including Kenya, Nigeria, South Africa and Uganda, has integrated available open-source software, services and tools, as well as public databases, for use by African and European biobanks and research institutions.

A box of cool tools

Partners brainstormed the specifications and modules needed for a new lab information management system, called Baobab LIMS, to be offered as a component of a biobank-in-a-box platform being developed by Bika Labs, a B3Africa partner. Meanwhile, South Africa’s NSB Biobank provided the LIMS use case, covering everything from lab kit assembly, sample storage and access policies to shipping and invoicing standards.

While developing standard data models for the platform, close attention was paid to data protection protocols in the EU and Africa. Emphasis was also placed on making the systems as easy to use and interoperable as possible. Bespoke training systems and a simplified user interface for bioinformatics workflow management, called Galaksio, were created to further help users.

“Once it is widely used, B3Africa’s ‘biobank-in-box’ management system will dramatically improve predictive, preventive and personalised healthcare worldwide,” predicts Bongcam-Rudloff, as the project puts the finishing touches on three years of work.

International imperatives … critical cooperation

Growing populations and rich genetic diversity are driving forces in the rapidly-evolving field of gene-based medicine and genomics, which makes African biobanks an “incredible resource of information to advance biomedical research”, according to the project team.

And international cooperation with African partners was critical to developing better research infrastructure and capabilities to tackle new medical threats and take advantage of advances in biotech and personalised healthcare.

“B3Africa’s training, infrastructure development and knowledge exchange tremendously expedited our biobanking and bioinformatics activities,” says project partner Moses L Joloba of Makerere University College of Health Sciences, Uganda. “We’ve also managed to lead the writing of the national guidelines for biobanking in Uganda and established a course in biorepository science here in the School of Biomedical Sciences’ Department of Immunology and Molecular Biology.”

Contributions from the H3Africa project, specialising in human heredity and health in Africa, and infrastructure supplied by the European Biobanking and Biomolecular Resources (BBMRI-ERIC) played an important role in B3Africa’s success. Working closely with the LMIC Biobank and Cohort Network (BCNet), the B3Africa team was able to harmonise the ethical and legal framework, as well as how data is collated, presented and shared among biobanks.

B3Africa provided the “critical mass” to deal with the fragmented biomedical research landscape, effectively integrating and leveraging existing biobanks and e-infrastructures in Europe and Africa.

Project details

  • Project acronym: B3Africa
  • Participants: Sweden (Coordinator), Austria, France, Kenya, Nigeria, Uganda, South Africa
  • Project N°: 654404
  • Total costs: € 2 035 250
  • EU contribution: € 2 035 250
  • Duration: July 2015 to June 2018

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