Optimising the impact and cost-effectiveness of child health intervention programmes of vaccines and micronutrients in low-income countries

back home
Print version Increase text Decrease text
Contract/Grant agreement number
: FP7-HEALTH-F3-2011-261375
EC contribution
: € 2,999,970.00
: 60 months
Starting date
: 01/03/2011
: Non-specific and sex-differential effects of vaccines and vitamin A, real life effects and cost-effectiveness, interactions between health interventions, measles vaccine, health and demographic surveillance systems, vitamin A supplementation, immunisation programmes, DTP, BCG, observational studies, randomised trial .
Project web-site
: http://bit.ly/1fAUTxu

To test the real life impact and cost effectiveness of child health interventions it is necessary to have individual-based data on health intervention uptake as well as on health status. The present project takes advantage of the Health and Demographic Surveillance Systems (HDSS) sites in the INDEPTH Network in Africa. The HDSS sites can provide the platform for

  1. assessing the real life effect and cost-effectiveness of interventions in observational studies;
  2. testing modifications of the current health intervention programs in randomised controlled trials (RCTs), and
  3. testing new interventions and their potential interactions with existing interventions in RCTs.

This programme is being implemented at three sites in Guinea-Bissau, Burkina Faso, and Ghana. Using the HDSSs as a platform OPTIMUNISE will test the four hypotheses formulated in a recent paper in Tropical Medicine and International Health (TMIH) about the negative non-specific and sex-differential effects of diphtheria-tetanus-pertussis (DTP) vaccine and the beneficial non-specific effects of measles vaccine (MV).

[+] Read More